Overexpression of chromosome 14 open reading frame 166 correlates with disease progression and poorer prognosis in human NPC
详细信息 查看全文
- 作者：Lin Yang ; Fengyan Li ; Fangyong Lei ; Yan Wang ; Shu Wu ; Libing Song…
- 关键词：C14orf166 ; Disease ; free survival ; NPC ; Overall survival ; Prognosis
- 刊名：Tumor Biology
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：36
- 期：10
- 页码：7977-7986
- 全文大小：2,147 KB
- 参考文献：1.Thompson MP, Kurzrock R. Epstein-Barr virus and cancer. Clin Cancer Res. 2004;10:803-1.CrossRef PubMed
2.Yu MC, Yuan JM. Epidemiology of nasopharyngeal carcinoma. Semin Cancer Biol. 2002;12:421-.CrossRef PubMed
3.Lai SZ, Li WF, Chen L, Luo W, Chen YY, Liu LZ, et al. How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients? Int J Radiat Oncol Biol Phys. 2011;80:661-.CrossRef PubMed
4.Xu L, Pan J, Wu J, Pan C, Zhang Y, Lin S, et al. Factors associated with overall survival in 1706 patients with nasopharyngeal carcinoma: significance of intensive neoadjuvant chemotherapy and radiation break. Radiother Oncol. 2010;96:94-.CrossRef PubMed
5.Wang Y, Klijn JG, Zhang Y, Sieuwerts AM, Look MP, Yang F, et al. Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet. 2005;365:671-.CrossRef PubMed
6.Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, et al. Molecular portraits of human breast tumours. Nature. 2000;406:747-2.CrossRef PubMed
7.Foo KF. Gemcitabine in metastatic nasopharyngeal carcinoma of the undifferentiated type. Ann Oncol. 2002;13:150-.CrossRef PubMed
8.Tan EH, Yang TL, Au E, Tao M, Ong YK, Chua EJK, et al. Phase II trial of a paclitaxel and carboplatin combination in Asian patients with metastatic nasopharyngeal carcinoma. Ann Oncol Off J Eur Soc Med Oncol ESMO. 1999;10:235-.CrossRef
9.Lupi I, Broman KW, Tzou SC, Gutenberg A, Martino E, Caturegli P. Novel autoantigens in autoimmune hypophysitis. Clin Endocrinol (Oxf). 2008;69:269-8.CrossRef
10.Perez-Gonzalez A, Pazo A, Navajas R, Ciordia S, Rodriguez-Frandsen A, Nieto A. hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex. PLoS One. 2014;9:e90957.PubMed Central CrossRef PubMed
11.Rodriguez A, Perez-Gonzalez A, Nieto A. Cellular human CLE/C14orf166 protein interacts with influenza virus polymerase and is required for viral replication. J Virol. 2011;85:12062-.PubMed Central CrossRef PubMed
12.Natasya NM, Hasnita CH, Shamim AK, Hasnan J, Fauziah MI, Narazah MY, et al. Chromosomal alterations in Malaysian patients with nasopharyngeal carcinoma analyzed by comparative genomic hybridization. Cancer Genet Cytogenet. 2010;203:309-2.CrossRef
13.Lee JW, Liao PC, Young KC, Chang CL, Chen SS, Chang TT, et al. Identification of hnRNPH1, NF45, and C14orf166 as novel host interacting partners of the mature hepatitis C virus core protein. J Proteome Res. 2011;10:4522-4.CrossRef PubMed
14.Wang J, Gu Y, Wang L, Hang X, Gao Y, Wang H, et al. HUPO BPP pilot study: a proteomics analysis of the mouse brain of different developmental stages. Proteomics. 2007;7:4008-5.CrossRef PubMed
15.Howng SL, Hsu HC, Cheng TS, Lee YL, Chang LK, Lu PJ, et al. A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors. Febs Lett. 2004;566:162-.CrossRef PubMed
16.Guo J, Wang W, Liao P, Lou W, Ji Y, Zhang C, et al. Identification of serum biomarkers for pancreatic adenocarcinoma by proteomic analysis. Cancer Sci. 2009;100:2292-01.CrossRef PubMed
17.Cui Y, Wu J, Zong M, Song G, Jia Q, Jiang J, et al. Proteomic profiling in pancreatic cancer with and without lymph node metastasis. Int J Cancer. 2009;124:1614-1.CrossRef PubMed
18.Howng SL, Hsu HC, Cheng TS, Lee YL, Chang LK, Lu PJ, et al. A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors. Febs Lett. 2004;566:162-.CrossRef PubMed
19.Wang J, Gu Y, Wang L, Hang X, Gao Y, Wang H, et al. HUPO BPP pilot study: a proteomics analysis of the mouse brain of different developmental stages. Proteomics. 2007;7:4008-5.CrossRef PubMed
20.Chang JT, Chan SC, Yen TC, Liao CT, Lin CY, Lin KJ, et al. Nasopharyngeal carcinoma staging by (18)F-fluorodeoxyglucose positron emission tomography. Int J Radiat Oncol Biol Phys. 2005;62:501-.CrossRef PubMed
21.Tang LQ, Chen QY, Fan W, Liu H, Zhang L, Guo L, et al. Prospective study of tailoring whole-body dual-modality [18F]fluorodeoxyglucose positron emission tomography/computed tomography with plasma Epstein-Barr virus DNA for detecting distant metastasis in endemic nasopharyngeal carcinoma at initial staging. J Clin Oncol. 2013;31:2861-.CrossRef PubMed
22.van Hooff SR, Leusink FK, Roepman P, Baatenburg DJR, Speel EJ, van den Brekel MW, et al. Validation of a gene expression signature for assessment of lymph node metastasis in oral squamous cell carcinoma. J Clin Oncol. 2012;30:4104-0.CrossRef PubMed
23.Cui Y, Wu J, Zong M, Song G, Jia Q, Jiang J, et al. Proteomic profiling in pancreatic cancer with and without lymph node metastasis. Int J Cancer. 2009;124:1614-1.CrossRef PubMed
24.Perez-Gonzalez A, Rodriguez A, Huarte M, Salanueva IJ, - 作者单位：Lin Yang (1)
Fengyan Li (1)
Fangyong Lei (1) (2)
Yan Wang (1) (2)
Shu Wu (1) (2)
Libing Song (1) (2)
Yong Chen (1) (2)
1. Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China
2. State Key Laboratory of Oncology in Southern China, Guangzhou, China - 刊物主题：Cancer Research;
- 出版者：Springer Netherlands
- ISSN：1423-0380
文摘
Chromosome 14 open reading frame 166 (c14orf166) contributes to regulation of centrosome architecture, transcription initiation, and RNA elongation and processing. However, the role of c14orf166 in human cancer remains unclear. This study aimed to investigate the expression and clinicopathological significance of c14orf166 in nasopharyngeal carcinoma (NPC). Real-time PCR and Western blotting analyses were employed to examine c14orf166 expression in immortalized primary nasopharyngeal epithelial cells (NP69), six NPC cell lines, three paired tumor samples and the adjacent noncancerous tissues from the same patients, and three additional tumor samples. Immunohistochemistry was performed to examine c14orf166 protein expression in archived paraffin-embedded tumor samples from 109 patients with clinicopathologically confirmed NPC. The association of c14orf166 expression with clinicopathological features and survival outcomes was assessed. C14orf166 messenger RNA and protein expression were upregulated in NPC cell lines and human tumor tissues compared to NP69 cells and noncancerous tissue samples, respectively. Immunohistochemical analyses revealed 104/109 (95.4 %) of the NPC tissue samples expressed c14orf166. High expression of c14orf166 (cutoff score >6) was significantly associated with gender (P--.016), clinical stage (P--.010), T classification (P--.013), N classification (P--.029), distant metastasis (P-lt;-.001), vital status (P--.001), and treatment method (P--.028; chi-square test). High c14orf166 expression was associated with significantly shorter overall survival (OS) and disease-free survival (DFS) than low c14orf166 expression. Multivariate analysis revealed c14orf166 was an independent prognostic indicator of OS and DFS in all patients (P--.046, P--.006) and was associated with poor OS and DFS in the subgroups with advanced clinical stage (P--.037, P--.001), lymph node metastasis (P--.001, P-lt;-.001), and T3–T4 disease (P--.005, P--.001), respectively. C14orf166 is overexpressed and may represent a novel prognostic factor in NPC. Keywords C14orf166 Disease-free survival NPC Overall survival Prognosis