Corticotropin-releasing factor overexpression in mice abrogates sex differences in body weight, visceral fat, and food intake response to a fast and alters levels of feeding regulatory hormones
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- 作者：Lixin Wang ; Miriam Goebel-Stengel ; Pu-Qing Yuan…
- 关键词：Adrenals ; Corticosterone ; CRF ; overexpressing mice ; Fasting ; Ghrelin ; Glucose ; Hypothalamic neuropeptide Y ; Insulin ; Leptin ; Sex difference ; Visceral fat
- 刊名：Biology of Sex Differences
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：8
- 期：1
- 全文大小：1155KB
- 刊物主题：Human Physiology; Endocrinology;
- 出版者：BioMed Central
- ISSN：2042-6410
- 卷排序：8
文摘
BackgroundCorticotropin-releasing factor overexpressing (CRF-OE) male mice showed an inhibited feeding response to a fast, and lower plasma acyl ghrelin and Fos expression in the arcuate nucleus compared to wild-type (WT) mice. We investigated whether hormones and hypothalamic feeding signals are impaired in CRF-OE mice and the influence of sex.