Development and characterization of multifunctional electrospun ferric oxide-gelatin-glycerol nanofibrous mat for wound dressing applications

详细信息    查看全文

• 作者：R. Morsy ; M. Hosny ; F. Reicha ; T. Elnimr
• 关键词：Ferric oxide ; Electrospun gelatin ; Trace element ; Wound dressing
• 刊名：Fibers and Polymers
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：17
• 期：12
• 页码：2014-2019
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Polymer Sciences;
• 出版者：The Korean Fiber Society
• ISSN：1875-0052
• 卷排序：17

文摘

In this study, we developed optimal multifunctional electrospun wound dressings possessing an antibacterial activity and rich in iron, a vital trace element for cell growth. Therefore, synthetic ferric oxide nanoparticles (α-Fe₂O₃ NPs) were ultrasonically dispersed into preheated gelatin-glycerol solution. A variety of techniques (X-ray diffraction (XRD), Fourier transform infrared (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), differential thermal analysis (DTA), in-vitro swelling-degradation studies and antibacterial tests) were used to characterize the electrospun mats. The results highlight that α-Fe₂O₃ NPs could be successfully dispersed into the electrospun gelatin nanofibers. The electrospun ferric oxide-gelatin-glycerol nanofibrous mats revealed free beads nanofibers with appropriated swelling-degradation behavior. It was observed that addition of α-Fe₂O₃ NPs enhanced the antibacterial activity of electrospun mats against positive and negative bacteria.