Formulation and In Vitro Characterization of Composite Biodegradable Magnetic Nanoparticles for Magnetically Guided Cell Delivery

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• 作者：Michael Chorny (12) chorny@email.chop.edu
  Ivan S. Alferiev (1)
  Ilia Fishbein (1)
  Jillian E. Tengood (1)
  Zo? Folchman-Wagner (1)
  Scott P. Forbes (1)
  Robert J. Levy (1)
• 关键词：KEY WORDS biodegradable nanoparticle – cell therapy – magnetic targeting – restenosis – stent angioplasty – vascular disease
• 刊名：Pharmaceutical Research
• 出版年：2012
• 出版时间：May 2012
• 年：2012
• 卷：29
• 期：5
• 页码：1232-1241
• 全文大小：602.8 KB
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• 作者单位：1. Division of Cardiology, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA2. The Children’s Hospital of Philadelphia, Abramson Research Building Suite 702 G, 3615 Civic Center Boulevard, Philadelphia, Pennsylvania 19104-4318, USA
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Pharmacy
  Biochemistry
  Medical Law
  Biomedical Engineering
  
• 出版者：Springer Netherlands
• ISSN：1573-904X

文摘

Purpose Cells modified with magnetically responsive nanoparticles (MNP) can provide the basis for novel targeted therapeutic strategies. However, improvements are required in the MNP design and cell treatment protocols to provide adequate magnetic properties in balance with acceptable cell viability and function. This study focused on select variables controlling the uptake and cell compatibility of biodegradable polymer-based MNP in cultured endothelial cells.