Temporal Variation in Physiological Biomarkers in Black Flying-Foxes (Pteropus alecto), Australia

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• 作者：Lee McMichael ; Daniel Edson ; David Mayer ; Amanda McLaughlin ; Lauren Goldspink…
• 关键词：Black flying ; fox ; Pteropus alecto ; biomarker ; haematology ; biochemistry ; urinalysis
• 刊名：EcoHealth
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：13
• 期：1
• 页码：49-59
• 全文大小：1,794 KB
• 参考文献：Algar D, Arnold GW, Grassia A (1988) Effects of nitrogen and season on western grey kangaroo hematology. Journal of Wildlife Management 52: 616-619CrossRef
  Bakken BH, Gerardo Herrera M, Carroll RM, Ayala-Berdo J, Schondube JE, del Rio CM (2008) A nectar feeding mammal avoids body fluid disturbances by varying renal function. Am J Physiol Renal Physiol 295: F1855–F1863
  Breed AC, Breed MF, Meers J, Field HE (2011) Evidence of endemic Hendra virus infection in flying-foxes (Pteropus conspicillatus) – Implications for disease risk management. Plos One 6(12):1-7CrossRef
  Calisher CH, Childs JE, Field HE, Holmes KV, Schountz T (2006) Bats: Important reservoir hosts of emerging viruses. Clinical Microbiology Reviews 19(3):531-545CrossRef PubMed PubMedCentral
  Churchill S (2008) Australian Bats. Allen & Unwin, Sydney, Australia
  Edson D, Field H, McMichael L, Vidgen M, Goldspink L, Broos A, Melville D, Kristoffersen J, De Jong C, McLaughlin A, Davis R, Kung N, Jordan D, Kirkland P, Smith C (2015) Routes of Hendra virus excretion in naturally-infected flying-foxes: Implications for viral transmission and spill-over risk. PLoS One 10(10): e0140670 (DOI: 10.​1371/​journal.​pone.​0140670 )CrossRef PubMed PubMedCentral
  Epstein JH, Prakash V, Smith CS, Daszak P, McLaughlin AB, Meehan G, Field HE, Cunningham AA (2008) Henipavirus infection in fruit bats (Pteropus giganteus), India. Emerg Infect Dis 14(8): 1309–1311CrossRef PubMed PubMedCentral
  Field HE (2005) The ecology of Hendra virus and Australian bat lyssavirus. PhD thesis, The University of Queensland, Brisbane, Australia
  Field HE, De Jong C, Melville D, Smith C, Smith I, Broos A, Kung YH, McLaughlin A, Zedderman A (2011) Hendra virus infection dynamics in Australian fruit bats. PLoS One 6:e28678CrossRef PubMed PubMedCentral
  Field HE, Crameri G, Kung NY, Wang LF (2012) Ecological aspects of Hendra virus. Current Topics in Microbiology and Immunology 359: 11-23PubMed
  Field H, Jordan D, Edson D, Morris S, Melville D, Parry-Jones K, Broos A, Divljan A, McMichael L, Davis R, Kung N, Kirkland P, Smith C (2015) Spatiotemporal aspects of Hendra virus infection in Pteropid bats (flying-foxes) in Eastern Australia. PLoS One 10(12): e0144055 (DOI: 10.​1371/​journal.​pone.​0144055 )CrossRef PubMed PubMedCentral
  GenStat (2013) GenStat for Windows, Release 15.3, Oxford: VSN International Ltd.
  Goldspink LK, Edson DW, Vidgen ME, Bingham J, Field HE, Smith CS (2015) Natural Hendra virus infection in Flying-foxes—tissue tropism and risk factors. PLoS ONE 10(6):e0128835 (DOI: 10.​1371/​journal.​pone.​0128835 )CrossRef PubMed PubMedCentral
  Green AJ (2001) Mass/length residuals: measures of body condition or generators of spurious results? Ecology 82(5), 1473-1483CrossRef
  Guidry AJ, Paape MJ, Pearson RE (1976) Effects of parturition and lactation on blood and milk cell concentrations, corticosteroids, and neutrophil phagocytosis in the cow. Am J Vet Res 37(10): 1195-2000PubMed
  Jackson S (2003) Australian Mammals: Biology and captive management. CSIRO Publishing, Clayton
  Jayme SI, Field HE, de Jong C, Olival KJ, Marsh G, Tagtag AM, Hughes T, Bucad A, Barr J, Azul RR, Retes LM, Foord A, Meng Y, Cruz MS, Santos IJ, Lim TMS, Benigno CC, Epstein JH, Wang L, Daszak P, Newman SH (2015) Molecular evidence of Ebola Reston virus infection in Philippine bats. Virology Journal 12:107 (DOI: 10.​1186/​s12985-015-0331-3 )CrossRef PubMed PubMedCentral
  Johnson-Delaney C (1996) Exotic Animal Companion Medicine Handbook for Veterinarians, Lake Worth, FL: Zoological Education Network
  Kessler EC, Gross JJ, Bruckmaier RM, Albrecht C (2014) Cholesterol metabolism, transport, and hepatic regulation in dairy cows during transition and early lactation. J Dairy Sci 97(9): 5481-90CrossRef PubMed
  Lindstedt SL, Boyce MS (1985) Seasonality, fasting endurance, and body size in mammals. Am Nat 125: 873-878CrossRef
  Markus N, Hall L (2004) Foraging Behaviour of the Black Flying-fox (Pteropus alecto) in the Urban Landscape of Brisbane, Queensland. Wildlife Research 31, 345-55CrossRef
  McCullagh P, Nelder JA (1989) Generalized Linear Models (2nd ed.). Chapman and Hall, LondonCrossRef
  MacIntosh AJJ, Huffman MA, Nishiwaki K, Miyabe-Nishiwaki T (2012) Urological screening of a wild group of Japanese macaques (Macaca fuscata yakui): investigating trends in nutrition and health. International Journal of Primatology 33, 460–478 CrossRef
  McMichael LA, Edson DW, McLaughlin A, Mayer D, Kopp S, Meers J, Field H (2015) Haematology and biochemistry of Pteropus alecto. PLoS One 10(5): e0125741 (DOI: 10.​1371/​journal.​pone.​0125741 )CrossRef PubMed PubMedCentral
  Merck Veterinary Manual (2015) http://​www.​merckmanuals.​com/​vet/​appendixes/​reference_​guides.​html
  Millar JS (1977) Adaptive Features of Mammalian Reproduction. Evolution 31(2): 370-386CrossRef
  Murray K, Selleck P, Hooper P, Hyatt A, Gould A, Gleeson L, Westbury H, Hiley L, Selvey L, Rodwell B, Ketterer P (1995) A Morbillivirus that caused fatal disease in horses and humans. Science 268(5207): 94-97CrossRef PubMed
  Palmer C, Woinarski JCZ (1999) Seasonal roosts and foraging movements of the black flying-fox Pteropus alecto in the Northern Territory: resource tracking in a landscape mosaic. Wildlife Research 26: 823-838CrossRef
  Plowright RK, Field HE, Smith C, Divljan A, Palmer C, Tabor G, Daszak P, Foley JE (2008) Reproductive and nutritional stress are risk factors for Hendra virus infection in little red flying foxes (Pteropus scapulatus). Proceedings of the Royal Society Biological Sciences 275(1636):861-869CrossRef
  Plowright RK, Eby P, Hudson P, Smith I, Westcott D, Bryden W, Middleton D, Reid PA, McFarlane RA, Martin G, Tabor GM, Skerratt LF, Anderson DL, Crameri G, Quammen D, Jordan D, Freeman P, Wang LF, Epstein JH, Marsh G, Kung NY, McCallum H (2015) Ecological dynamics of emerging bat virus spillover. Proc. R. Soc B 282: 20142124CrossRef
  Riedesel ML (1977) Blood Physiology. In: Wimsatt WA (ed) Biology of bats, vol 3. Academic Press, New York
  Roulston TH, Cane JH (2000) Pollen nutritional content and digestibility for animals. Plant Systematics and Evolution 222: 189-209CrossRef
  Ruykys, Rich B, McCarthy P (2012) Haematology and biochemistry of warru (Petrogale lateralis MacDonnell Ranges race) in captivity and the wild. Australian Veterinary Journal 90:9, 331-340CrossRef PubMed
  Smith C, Skelly C, Kung N, Roberts B, Field H (2014) Flying-fox species density - a spatial risk factor for Hendra virus infection in horses in Eastern Australia. PLoS One 9(6): e99965 (DOI: 10.​1371/​journal.​pone.​0099965 )CrossRef PubMed PubMedCentral
  Smith CS, de Jong CE, Meers J, Henning J, Wang L-F, Field HE (2016) Coronavirus infection and diversity in bats in the Australasian region. EcoHealth. doi:10.​1007/​s10393-016-1116-x
  Srivastava RK, Krishna A (2008) Seasonal adiposity, correlative changes in metabolic factors and unique reproductive activity in a Vespertilinonid bat, Scotophilus heathi. J Exp Zool 309A: 94-110CrossRef
  Studier EH, Wilson DE (1983) Natural urine concentrations and composition in neotropical bats. Comparative Biochemistry and Physiology 75A (4), 509-515CrossRef
  Thometz NM, Tinker MT, Staedler MM, Mayer KA, Williams TM (2014) Energetic demands of immature sea otters from birth to weaning: implications for maternal costs, reproductive behaviour and population-level trends. J Exp Biol 217(12): 2053-2061CrossRef PubMed
  Wagner J (2008) Glandular secretions of male Pteropus (Flying foxes): preliminary chemical comparisons among species. Independent Study Project (ISP) Collection, Paper 559
  Welbergen JA (2011) Fit females and fat polygynous males: seasonal body mass changes in the grey-headed flying fox. Oecologica 165: 629-637CrossRef
  Welbergen JA (2014) Killer Climate: Tens of Thousands of Flying-Foxes Dead in a Day. Richmond: Hawesbury Institute for the Environment, University of Western Sydney. http://​www.​uws.​edu.​au/​hie/​events_​and_​seminars/​killer_​climate_​tens_​of_​thousands_​of_​flying_​foxes_​dead_​in_​a_​day .
  
• 作者单位：Lee McMichael (1) (2)
  Daniel Edson (2) (6)
  David Mayer (3)
  Amanda McLaughlin (2)
  Lauren Goldspink (2)
  Miranda E. Vidgen (4)
  Steven Kopp (1)
  Joanne Meers (1)
  Hume Field (5)
  
  1. School of Veterinary Science, University of Queensland, Gatton, QLD, 4343, Australia
  2. Biosecurity Queensland, Department of Agriculture and Fisheries, Brisbane, QLD, 4108, Australia
  6. Department of Agriculture and Water Resources, Canberra, ACT, 2601, Australia
  3. Department of Agriculture and Fisheries, Brisbane, QLD, 4103, Australia
  4. School of Science and Engineering, University of the Sunshine Coast, Sippy Downs, QLD, 4556, Australia
  5. Ecohealth Alliance, New York, NY, 10001, USA
  
• 刊物类别：Earth and Environmental Science
• 刊物主题：Environment
  Environment
  Public Health
  Environmental Medicine/Environmental Psychology
  Ecosystems
  Environmental Management
  Microbiology
  
• 出版者：Springer New York
• ISSN：1612-9210

文摘

Bats of the genus Pteropus (Pteropodidae) are recognised as the natural host of multiple emerging pathogenic viruses of animal and human health significance, including henipaviruses, lyssaviruses and ebolaviruses. Some studies have suggested that physiological and ecological factors may be associated with Hendra virus infection in flying-foxes in Australia; however, it is essential to understand the normal range and seasonal variability of physiological biomarkers before seeking physiological associations with infection status. We aimed to measure a suite of physiological biomarkers in P. alecto over time to identify any seasonal fluctuations and to examine possible associations with life-cycle and environmental stressors. We sampled 839 adult P. alecto in the Australian state of Queensland over a 12-month period. The adjusted population means of every assessed hematologic and biochemical parameter were within the reported reference range on every sampling occasion. However, within this range, we identified significant temporal variation in these parameters, in urinary parameters and body condition, which primarily reflected the normal annual life cycle. We found no evident effect of remarkable physiological demands or nutritional stress, and no indication of clinical disease driving any parameter values outside the normal species reference range. Our findings identify underlying temporal physiological changes at the population level that inform epidemiological studies and assessment of putative physiological risk factors driving Hendra virus infection in P. alecto. More broadly, the findings add to the knowledge of Pteropus populations in terms of their relative resistance and resilience to emerging infectious disease.