Laser Desorption Ionization Quadrupole Ion Trap Time-of-Flight Mass Spectrometry of Au _m Fe _n ^+/– Clusters Generated from Gold-Iron Nanoparticles and their Giant Nanoflowers. Electrochemical and/or

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• 作者：Ravi Madhukar Mawale ; Mayuri Vilas Ausekar…
• 关键词：Mass spectrometry ; Nanoparticles ; Nanoflowers ; Plasma ; assisted ; Stainless steel ; Laser desorption ionization
• 刊名：Journal of The American Society for Mass Spectrometry
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：28
• 期：2
• 页码：215-223
• 全文大小：
• 刊物主题：Analytical Chemistry; Biotechnology; Organic Chemistry; Proteomics; Bioinformatics;
• 出版者：Springer US
• ISSN：1879-1123
• 卷排序：28

文摘

Gold nanoparticles (NP) with average diameter ~100 nm synthesized from tetrachloroauric acid solution using stainless steel as a reducing agent were found to contain iron. Applying simultaneously high frequency (HF) plasma discharge in solution during the electrochemical reduction, giant gold-iron nanoflowers with average size ~1000–5000 nm were formed. Scanning electron microscopy (SEM) shows the morphology of the nanopowders produced as polygonal yet nearly spherical, whereas iron content in both products determined by energy dispersive X-ray analysis (EDX) was found to be at ~2.5 at. %. Laser desorption ionization (LDI) of both nanomaterials and mass spectrometric analysis show the formation of Au_mFe_n+/– (m = 1–35; n = 1–3) clusters. Structure of few selected clusters in neutral or monocharged forms were computed by density functional theory (DFT) calculations and it was found that typical distances of an iron nucleus from adjacent gold nuclei lie in the interval 2.5 to 2.7 Å. Synthetized Au-Fe nanoparticles were found stable for at least 2 mo at room temperature (even in aqueous solution) without any stabilizing agent. Produced Au-Fe nanoparticles in combination with standard MALDI matrices enhance ionization of peptides and might find use in nanomedicine.