Lithium ions attenuate serum-deprivation-induced apoptosis in PC12 cells through regulation of the Akt/FoxO1 signaling pathways

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• 作者：Zhiwen Zeng ; Haitao Wang ; Fu Shang ; Lihua Zhou ; Peter J. Little…
• 关键词：Lithium ; Serum deprivation ; Apoptosis ; PI3K/Akt/FoxO1 ; Neuroprotection
• 刊名：Psychopharmacology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：233
• 期：5
• 页码：785-794
• 全文大小：1,541 KB
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• 作者单位：Zhiwen Zeng (1) (2)
  Haitao Wang (3)
  Fu Shang (3)
  Lihua Zhou (4)
  Peter J. Little (5)
  Remi Quirion (6)
  Wenhua Zheng (1)
  
  1. Faculty of Health Science, University of Macau, Room 4021, Building E12, Avenida de Universidade Taipa, Macau, People’s Republic of China
  2. Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Collaborative Innovation Center for Neurogenetics and Channelopathies, Institute of Neuroscience, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China
  3. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center and Neurophamacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510060, People’s Republic of China
  4. Zhongshan Medical School, Sun Yat-Sen University, Guangzhou, 510060, People’s Republic of China
  5. School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, 20 Cornwall St, Woolloongabba, QLD, 4102, Australia
  6. Douglas Hospital Research Center, McGill University, Montreal, Canada
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2072

文摘

Rationale Lithium is currently used in the treatment of mental illness. We have previously reported that lithium stimulated the protein kinase B/Forkhead box O1 (Akt/FoxO1) pathway in rats. However, little information is available regarding its neuroprotective role of this pathway and underlying mechanisms.