Longitudinal analysis of treatment-induced genomic alterations in gliomas

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• 作者：E. Zeynep Erson-Omay ; Octavian Henegariu ; S. Bülent Omay…
• 关键词：Genomics ; guided precision medicine ; Tumor evolution ; Longitudinal genomic analysis ; Immune checkpoint inhibition ; Mismatch repair deficiency ; Glioma
• 刊名：Genome Medicine
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：9
• 期：1
• 全文大小：2466KB
• 刊物主题：Human Genetics; Metabolomics; Bioinformatics; Medicine/Public Health, general; Cancer Research; Systems Biology;
• 出版者：BioMed Central
• ISSN：1756-994X
• 卷排序：9

文摘

BackgroundGlioblastoma multiforme (GBM) constitutes nearly half of all malignant brain tumors and has a median survival of 15 months. The standard treatment for these lesions includes maximal resection, radiotherapy, and chemotherapy; however, individual tumors display immense variability in their response to these approaches. Genomic techniques such as whole-exome sequencing (WES) provide an opportunity to understand the molecular basis of this variability.