The anti-inflammatory secoiridoid glycosides from Gentianae Scabrae Radix: the root and rhizome of Gentiana scabra
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- 作者：Yu-Min He ; Shu Zhu ; Yue-Wei Ge ; Kohei Kazuma ; Kun Zou…
- 关键词：Secoiridoid glycosides ; Gentiana scabra ; Gentianaceae ; Anti ; inflammatory activity ; 8 ; epi ; kingiside derivative ; Kingiside derivative
- 刊名：Journal of Natural Medicines
- 出版年：2015
- 出版时间：July 2015
- 年：2015
- 卷：69
- 期：3
- 页码：303-312
- 全文大小：880 KB
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Shu Zhu (1)
Yue-Wei Ge (1)
Kohei Kazuma (3)
Kun Zou (2)
Shao-Qing Cai (4)
Katsuko Komatsu (1)
1. Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama, 2630, Sugitani, Toyama, 930-0194, Japan
2. College of Medical Science, China Three Gorges University, 8 University Avenue, Yichang, 443002, People’s Republic of China
3. Division of Kampo-Pharmaceutics, Institute of Natural Medicine, University of Toyama, 2630, Sugitani, Toyama, 930-0194, Japan
4. School of Pharmaceutical Sciences, Peking University, 38 Xue-yuan Road, Haidian District, Beijing, 100191, People’s Republic of China - 刊物主题：Pharmacology/Toxicology; Plant Sciences; Complementary & Alternative Medicine; Medicinal Chemistry; Pharmacy;
- 出版者：Springer Japan
- ISSN：1861-0293
文摘
Gentianae Scabrae Radix is a well-known traditional medicine that is used for the treatment of hepatitis, cholecystitis and inflammatory diseases. It consists mainly of secoiridoid glycosides, with representatives of gentiopicroside, sweroside and swertiamarin. In the present study, a chemical investigation of the CHCl3 extract of Gentianae Scabrae Radix derived from Gentiana scabra Bunge yielded seven new (1-strong class="EmphasisTypeBold">7) and ten known (8-strong class="EmphasisTypeBold">17) secoiridoid glycosides. Their structures were elucidated by extensive spectroscopic analyses and comparison with literature data. All 17 compounds were evaluated for their inhibitory effects against NO, IL-6 and TNF-α productions induced by lipopolysaccharide (LPS) in RAW264 cells. Among them, 8-epi-kingiside derivatives 1-strong class="EmphasisTypeBold">3; kingiside derivatives 4, 5 and 10; and a sweroside derivative 6 showed inhibition activity against IL-6 production with IC50 values of 51.70-1.10?μM, whereas sweroside derivatives 12 and 15-strong class="EmphasisTypeBold">17 and a swertiamarin derivative 13 showed inhibition effects on both NO and IL-6 productions with IC50 values of 64.74-4.95 and 48.91-5.45?μM, respectively. All the compounds exhibited weak inhibitory activity (IC50?>?100?μM) in a TNF-α bioassay. Finally, a primary structure–activity relationship of these secoiridoid glycosides is discussed.