Neuropathology of cigarette smoking

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• 作者：Raymond Chuen-Chung Chang (1) (2) (3)
  Yuen-Shan Ho (4)
  Shun Wong (5)
  Stephen M. Gentleman (6)
  Ho-Keung Ng (7)
  
• 关键词：Cigarette smoking ; Atherosclerosis ; Neurodegeneration ; Alzheimer’s disease ; Parkinson’s disease ; Prenatal exposure to maternal cigarette smoking
• 刊名：Acta Neuropathologica
• 出版年：2014
• 出版时间：January 2014
• 年：2014
• 卷：127
• 期：1
• 页码：53-69
• 全文大小：901 KB
• 作者单位：Raymond Chuen-Chung Chang (1) (2) (3)
  Yuen-Shan Ho (4)
  Shun Wong (5)
  Stephen M. Gentleman (6)
  Ho-Keung Ng (7)
  
  1. Laboratory of Neurodegenerative Diseases, Department of Anatomy, LKS Faculty of Medicine, The University of Hong Kong, Rm. L1-49, Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong
  2. State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Pokfulam, Hong Kong
  3. Research Centre of Heart, Brain, Hormone and Healthy Aging, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
  4. State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau
  5. Department of Pathology, Prince Margret Hospital, Kowloon, Hong Kong
  6. Neuropathology Unit, Department of Medicine, Imperial College London, London, UK
  7. Department of Anatomical and Cellular Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
  
• ISSN：1432-0533

文摘

It is well established that cigarette smoking is hazardous to health and is a risk factor for many chronic diseases. However, its impact on the brain, whether it be from prenatal exposure to maternal cigarette smoking, cerebrovascular disease, Alzheimer’s disease (AD) or Parkinson’s disease, is still not very clear. Neuroimaging and neuropathological investigations suggest that there are heterogeneous effects of cigarette smoking on the brain. On the one hand, it is quite clear that cigarette smoking causes damage to endothelial cells, resulting in increased risk of cerebrovascular disease. On the other hand, it seems to be associated with different Alzheimer’s pathologies in post-mortem brains and experimental models, despite the fact that epidemiological studies clearly indicate a positive correlation between cigarette smoking and increased risk for AD. Interestingly, cigarette smoking appears to be associated with reduced Parkinson’s pathology in post-mortem brains. However, although nicotine in cigarettes may have some neuroprotective actions, the effects of all the other toxic compounds in cigarettes cannot be ignored. It is, therefore, our aim to summarize what is known about the neuropathology of cigarette smoking and, in particular, its implications for neurodegenerative diseases.