Radiotherapy in the management of gist: state of the art and new potential scenarios
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- 作者：L. Gatto ; M. Nannini ; M. Saponara ; V. Di Scioscio ; G. Beltramo…
- 关键词：Radiotherapy ; GIST ; Treatment
- 刊名：Clinical Sarcoma Research
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：7
- 期：1
- 全文大小：1044KB
- 刊物主题：Cancer Research; Oncology; Surgical Oncology;
- 出版者：BioMed Central
- ISSN：2045-3329
- 卷排序：7
文摘
BackgroundGastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract. The main treatment for localized gastrointestinal stromal tumors is surgical resection. Unresectable or advanced GIST are poorly responsive to conventional cytotoxic chemotherapy but the introduction of tyrosine kinase inhibitors (TKIs) marked a revolutionary step in the treatment of these patients, radically improving prognosis and clinical benefit. Historically GIST has been considered radiation-resistant, and the role of radiotherapy in the management of patients with GIST is currently restricted to symptomatic palliation in current treatment guidelines.