Benchmark dose for cadmium exposure and elevated N-acetyl-β-d-glucosaminidase: a meta-analysis

详细信息    查看全文

• 作者：CuiXia Liu ; YuBiao Li ; ChunShui Zhu…
• 关键词：Benchmark dose ; Cadmium ; Meta ; analysis ; N ; acetyl ; β ; d ; glucosaminidase
• 刊名：Environmental Science and Pollution Research
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：23
• 期：20
• 页码：20528-20538
• 全文大小：578 KB
• 刊物类别：Earth and Environmental Science
• 刊物主题：Environment
  Environment
  Atmospheric Protection, Air Quality Control and Air Pollution
  Waste Water Technology, Water Pollution Control, Water Management and Aquatic Pollution
  Industrial Pollution Prevention
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1614-7499
• 卷排序：23

文摘

Cadmium (Cd) is a well-known nephrotoxic contaminant, and N-acetyl-β-d-glucosaminidase (NAG) is considered to be an early and sensitive marker of tubular dysfunction. The link between Cd exposure and NAG level enables us to derive the benchmark dose (BMD) of Cd. Although several reports have already documented urinary Cd (UCd)-NAG relationships and BMD estimations, high heterogeneities arise due to the sub-populations (age, gender, and ethnicity) and BMD methodologies being employed. To clarify the influences that these variables exert, firstly, a random effect meta-analysis was performed in this study to correlate the UCd and NAG based on 92 datasets collected from 30 publications. Later, this established correlation (Ln(NAG) = 0.51 × Ln(UCd) + 0.83) was applied to derive the UCd BMD₅ of 1.76 μg/g creatinine and 95 % lower confidence limit of BMD₅ (BMDL₅) of 1.67 μg/g creatinine. While the regressions for different age groups and genders differed slightly, it is age and not gender that significantly affects BMD estimations. Ethnic differences may require further investigation given that limited data is currently available. Based on a comprehensive and systematic literature review, this study is a new attempt to quantify the UCd-NAG link and estimate BMD.