Recent developments in therapeutic protein expression technologies in plants

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• 作者：Shah Fahad (1)
  Faheem Ahmed Khan (2) (3)
  Nuruliarizki Shinta Pandupuspitasari (3)
  Muhammad Mahmood Ahmed (4)
  Yu Cai Liao (4)
  Muhammad Tahir Waheed (5)
  Muhammad Sameeullah (8)
  Darkhshan (9)
  Saddam Hussain (1)
  Shah Saud (6)
  Shah Hassan (7)
  Amanullah Jan (7)
  Mohammad Tariq Jan (7)
  Chao Wu (1)
  Ma Xiao Chun (1)
  Jianliang Huang (1)
  
  1. National Key Laboratory of Crop Genetic Improvement ; MOA Key Laboratory of Crop Ecophysiology and Farming System in the Middle Reaches of the Yangtze River ; College of Plant Science and Technology ; Huazhong Agricultural University ; No. 1 Shizishan Street ; Hongshan District ; Wuhan ; 430070 ; Hubei ; China
  2. Molecular Biotechnology Laboratory for Triticeae Crops ; Huazhong Agricultural University ; Wuhan ; China
  3. Key Laboratory of Agricultural Animal Genetics ; Breeding and Reproduction ; Huazhong Agricultural University ; Wuhan ; 430070 ; China
  4. College of Plant Science and Technology ; Huazhong Agricultural University ; Wuhan ; China
  5. Department of Biochemistry ; Quaid-I-Azam University ; Islamabad ; Pakistan
  8. Biotechnology Lab. ; Department of Biology ; Faculty of Science and Arts ; Abant Izzet Baysal University ; Golkoy Campus ; 14280 ; Bolu ; Turkey
  9. Women Institute of Learning ; Abbottabad ; Pakistan
  6. Department of Horticultural ; Northeast Agricultural University ; Harbin ; 150030 ; China
  7. Agriculture University ; Peshawar ; 25000 ; Pakistan
  
• 关键词：Antibodies ; Bacterial cells ; Biopharmaceuticals ; Mammalian cells ; Protein expression ; Vaccines
• 刊名：Biotechnology Letters
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：37
• 期：2
• 页码：265-279
• 全文大小：359 KB
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• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Microbiology
  Biotechnology
  Applied Microbiology
  Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-6776

文摘

Infectious diseases and cancers are some of the commonest causes of deaths throughout the world. The previous two decades have witnessed a combined endeavor across various biological sciences to address this issue in novel ways. The advent of recombinant DNA technologies has provided the tools for producing recombinant proteins that can be used as therapeutic agents. A number of expression systems have been developed for the production of pharmaceutical products. Recently, advances have been made using plants as bioreactors to produce therapeutic proteins directed against infectious diseases and cancers. This review highlights the recent progress in therapeutic protein expression in plants (stable and transient), the factors affecting heterologous protein expression, vector systems and recent developments in existing technologies and steps towards the industrial production of plant-made vaccines, antibodies, and biopharmaceuticals.