VapC toxin inhibition as a method for prevention of the formation of resting forms of mycobacteria

详细信息    查看全文

• 作者：O. I. Demidenok ; M. S. Shumkov ; A. V. Goncharenko
• 关键词：toxin ; antitoxin systems ; vapBC ; dormant mycobacteria ; ovoids
• 刊名：Applied Biochemistry and Microbiology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：52
• 期：6
• 页码：589-592
• 全文大小：418 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Microbiology
  Medical Microbiology
  Russian Library of Science
  
• 出版者：MAIK Nauka/Interperiodica distributed exclusively by Springer Science+Business Media LLC.
• ISSN：1608-3024
• 卷排序：52

文摘

It has been shown that inactivation of the VapC toxin from the VapВС toxin-antitoxin system prevents mycobacterial cells from transitioning to an ovoid state that meets the criteria of dormancy. The results indicate a potential target for medicines that prevent the development of latent tuberculosis infection and provide a basis to obtain bacterial cells for the testing of compounds that are active towards dormant forms of mycobacteria.