Placental ischemia induces changes in gene expression in chorionic tissue
详细信息 查看全文
- 作者：Eric M. George (1)
Michael R. Garrett (2)
Joey P. Granger (1) - 刊名：Mammalian Genome
- 出版年：2014
- 出版时间：June 2014
- 年：2014
- 卷：25
- 期：5-6
- 页码：253-261
- 全文大小：
- 参考文献：1. Ain R, Tash JS, Soares MJ (2003) Prolactin-like protein-A is a functional modulator of natural killer cells at the maternal-fetal interface. Mol Cell Endocrinol 204:65-4 CrossRef
2. Alam SM, Ain R, Konno T, Ho-Chen JK, Soares MJ (2006) The rat prolactin gene family locus: species-specific gene family expansion. Mamm Genome Off J Int Mamm Genome Soc 17:858-77 CrossRef
3. Alam SM, Konno T, Sahgal N, Lu L, Soares MJ (2008) Decidual cells produce a heparin-binding prolactin family cytokine with putative intrauterine regulatory actions. J Biol Chem 283:18957-8968 CrossRef
4. Alexander BT, Cockrell K, Cline FD, Llinas MT, Sedeek M, Granger JP (2001) Effect of angiotensin II synthesis blockade on the hypertensive response to chronic reductions in uterine perfusion pressure in pregnant rats. Hypertension 38:742-45 CrossRef
5. Baldocchi RA, Tan L, King DS, Nicoll CS (1993) Mass spectrometric analysis of the fragments produced by cleavage and reduction of rat prolactin: evidence that the cleaving enzyme is cathepsin D. Endocrinology 133:935-38
6. Bamberger AM, Sudahl S, Loning T, Wagener C, Bamberger CM, Drakakis P, Coutifaris C, Makrigiannakis A (2000) The adhesion molecule CEACAM1 (CD66a, C-CAM, BGP) is specifically expressed by the extravillous intermediate trophoblast. Am J Pathol 156:1165-170 CrossRef
7. Bebo BF Jr, Dveksler GS (2005) Evidence that pregnancy specific glycoproteins regulate T-cell function and inflammatory autoimmune disease during pregnancy. Curr Drug Targets Inflamm Allergy 4:231-37 CrossRef
8. Bergmann A, Ahmad S, Cudmore M, Gruber AD, Wittschen P, Lindenmaier W, Christofori G, Gross V, Gonzalves A, Grone HJ, Ahmed A, Weich HA (2010) Reduction of circulating soluble Flt-1 alleviates preeclampsia-like symptoms in a mouse model. J Cell Mol Med 14:1857-867 CrossRef
9. Bridges JP, Gilbert JS, Colson D, Gilbert SA, Dukes MP, Ryan MJ, Granger JP (2009) Oxidative stress contributes to soluble fms-like tyrosine kinase-1 induced vascular dysfunction in pregnant rats. Am J Hypertens 22:564-68 CrossRef
10. Buimer M, Keijser R, Jebbink JM, Wehkamp D, van Kampen AH, Boer K, van der Post JA, Ris-Stalpers C (2008) Seven placental transcripts characterize HELLP-syndrome. Placenta 29:444-53 CrossRef
11. Centlow M, Wingren C, Borrebaeck C, Brownstein MJ, Hansson SR (2011) Differential gene expression analysis of placentas with increased vascular resistance and pre-eclampsia using whole-genome microarrays. J Pregnancy 2011:472354 CrossRef
12. Clapp C, Aranda J, Gonzalez C, Jeziorski MC, Martinez de la Escalera G (2006) Vasoinhibins: endogenous regulators of angiogenesis and vascular function. Trends Endocrinol Metab TEM 17:301-07 CrossRef
13. Cox B, Sharma P, Evangelou AI, Whiteley K, Ignatchenko V, Ignatchenko A, Baczyk D, Czikk M, Kingdom J, Rossant J, Gramolini AO, Adamson SL, Kislinger T (2011) Translational analysis of mouse and human placental protein and mRNA reveals distinct molecular pathologies in human preeclampsia. Mol Cell Proteomics MCP 10(M111):012526
14. Croce K, Gao H, Wang Y, Mooroka T, Sakuma M, Shi C, Sukhova GK, Packard RR, Hogg N, Libby P, Simon DI (2009) Myeloid-related protein-8/14 is critical for the biological response to vascular injury. Circulation 120:427-36 CrossRef
15. D’Angelo G, Struman I, Martial J, Weiner RI (1995) Activation of mitogen-activated protein kinases by vascular endothelial growth factor and basic fibroblast growth factor in capillary endothelial cells is inhibited by the antiangiogenic factor 16-kDa N-terminal fragment of prolactin. Proc Natl Acad Sci USA 92:6374-378 CrossRef
16. D’Angelo G, Martini JF, Iiri T, Fantl WJ, Martial J, Weiner RI (1999) 16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells. Mol Endocrinol 13:692-04 CrossRef
17. Enquobahrie DA, Meller M, Rice K, Psaty BM, Siscovick DS, Williams MA (2008) Differential placental gene expression in preeclampsia. Am J Obstet Gynecol 199(566):511-61
18. Ergun S, Kilik N, Ziegeler G, Hansen A, Nollau P, Gotze J, Wurmbach JH, Horst A, Weil J, Fernando M, Wagener C (2000) CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor. Mol Cell 5:311-20 CrossRef
19. Founds SA, Conley YP, Lyons-Weiler JF, Jeyabalan A, Hogge WA, Conrad KP (2009) Altered global gene expression in first trimester placentas of women destined to develop preeclampsia. Placenta 30:15-4 CrossRef
20. Goyal R, Yellon SM, Longo LD, Mata-Greenwood E (2010) Placental gene expression in a rat ‘model-of placental insufficiency. Placenta 31:568-75 CrossRef
21. Gray-Owen SD, Blumberg RS (2006) CEACAM1: contact-dependent control of immunity. Nat Rev Immunol 6:433-46 CrossRef
22. Heinzel K, Benz C, Bleul CC (2007) A silent chemokine receptor regulates steady-state leukocyte homing in vivo. Proc Natl Acad Sci USA 104:8421-426 CrossRef
23. Hladunewich M, Karumanchi SA, Lafayette R (2007) Pathophysiology of the clinical manifestations of preeclampsia. Clin J Am Soc Nephrol 2:543-49 CrossRef
24. Khong Y, Brosens I (2010) Defective deep placentation. Best Pract Res Clin Obstet Gynaecol 25:301-11 CrossRef
25. Kupferminc MJ, Peaceman AM, Wigton TR, Rehnberg KA, Socol ML (1994) Tumor necrosis factor-alpha is elevated in plasma and amniotic fluid of patients with severe preeclampsia. Am J Obstet Gynecol 170:1752-757; discussion 1757-759
26. LaMarca BB, Cockrell K, Sullivan E, Bennett W, Granger JP (2005) Role of endothelin in mediating tumor necrosis factor-induced hypertension in pregnant rats. Hypertension 46:82-6 CrossRef
27. LaMarca B, Parrish M, Ray LF, Murphy SR, Roberts L, Glover P, Wallukat G, Wenzel K, Cockrell K, Martin JN Jr, Ryan MJ, Dechend R (2009) Hypertension in response to autoantibodies to the angiotensin II type I receptor (AT1-AA) in pregnant rats: role of endothelin-1. Hypertension 54:905-09 CrossRef
28. Leanos-Miranda A, Marquez-Acosta J, Cardenas-Mondragon GM, Chinolla-Arellano ZL, Rivera-Leanos R, Bermejo-Huerta S, Romero-Arauz JF, Alvarez-Jimenez G, Ramos-Leon JC, Ulloa-Aguirre A (2008) Urinary prolactin as a reliable marker for preeclampsia, its severity, and the occurrence of adverse pregnancy outcomes. J Clin Endocrinol Metab 93:2492-499 CrossRef
29. Leanos-Miranda A, Campos-Galicia I, Ramirez-Valenzuela KL, Chinolla-Arellano ZL, Isordia-Salas I (2013) Circulating angiogenic factors and urinary prolactin as predictors of adverse outcomes in women with preeclampsia. Hypertension 61:1118-125 CrossRef
30. Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, Libermann TA, Morgan JP, Sellke FW, Stillman IE, Epstein FH, Sukhatme VP, Karumanchi SA (2003) Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Investig 111:649-58 CrossRef
31. Meng T, Chen H, Sun M, Wang H, Zhao G, Wang X (2012) Identification of differential gene expression profiles in placentas from preeclamptic pregnancies versus normal pregnancies by DNA microarrays. OMICS 16:301-11 CrossRef
32. Nenan S, Boichot E, Lagente V, Bertrand CP (2005) Macrophage elastase (MMP-12): a pro-inflammatory mediator? Mem Inst Oswaldo Cruz 100(Suppl 1):167-72 CrossRef
33. Nenan S, Lagente V, Planquois JM, Hitier S, Berna P, Bertrand CP, Boichot E (2007) Metalloelastase (MMP-12) induced inflammatory response in mice airways: effects of dexamethasone, rolipram and marimastat. Eur J Pharmacol 559:75-1 CrossRef
34. Nouvion AL, Oubaha M, Leblanc S, Davis EC, Jastrow H, Kammerer R, Breton V, Turbide C, Ergun S, Gratton JP, Beauchemin N (2010) CEACAM1: a key regulator of vascular permeability. J Cell Sci 123:4221-230 CrossRef
35. Nucera S, Biziato D, De Palma M (2011) The interplay between macrophages and angiogenesis in development, tissue injury and regeneration. Int J Dev Biol 55:495-03 CrossRef
36. Orwig KE, Soares MJ (1999) Transcriptional activation of the decidual/trophoblast prolactin-related protein gene. Endocrinology 140:4032-039
37. Piwnica D, Touraine P, Struman I, Tabruyn S, Bolbach G, Clapp C, Martial JA, Kelly PA, Goffin V (2004) Cathepsin D processes human prolactin into multiple 16K-like N-terminal fragments: study of their antiangiogenic properties and physiological relevance. Mol Endocrinol 18:2522-542 CrossRef
38. Prakobphol A, Genbacev O, Gormley M, Kapidzic M, Fisher SJ (2006) A role for the L-selectin adhesion system in mediating cytotrophoblast emigration from the placenta. Dev Biol 298:107-17 CrossRef
39. Redman CW, Bonnar J, Beilin LJ, McNeilly AS (1975) Prolactin in hypertensive pregnancy. Br Med J 1:304-06 CrossRef
40. Reimer T, Koczan D, Gerber B, Richter D, Thiesen HJ, Friese K (2002) Microarray analysis of differentially expressed genes in placental tissue of pre-eclampsia: up-regulation of obesity-related genes. Mol Hum Reprod 8:674-80 CrossRef
41. Roberts JM, Pearson G, Cutler J, Lindheimer M (2003) Summary of the NHLBI working group on research on hypertension during pregnancy. Hypertension 41:437-45 CrossRef
42. Sedeek M, Gilbert JS, LaMarca BB, Sholook M, Chandler DL, Wang Y, Granger JP (2008) Role of reactive oxygen species in hypertension produced by reduced uterine perfusion in pregnant rats. Am J Hypertens 21:1152-156 CrossRef
43. Sibai B, Dekker G, Kupferminc M (2005) Pre-eclampsia. Lancet 365:785-99 CrossRef
44. Snyder SK, Wessner DH, Wessells JL, Waterhouse RM, Wahl LM, Zimmermann W, Dveksler GS (2001) Pregnancy-specific glycoproteins function as immunomodulators by inducing secretion of IL-10, IL-6 and TGF-beta1 by human monocytes. Am J Reprod Immunol 45:205-16 CrossRef
45. Soares MJ, Konno T, Alam SM (2007) The prolactin family: effectors of pregnancy-dependent adaptations. Trends Endocrinol Metab TEM 18:114-21 CrossRef
46. Struman I, Bentzien F, Lee H, Mainfroid V, D’Angelo G, Goffin V, Weiner RI, Martial JA (1999) Opposing actions of intact and N-terminal fragments of the human prolactin/growth hormone family members on angiogenesis: an efficient mechanism for the regulation of angiogenesis. Proc Natl Acad Sci USA 96:1246-251 CrossRef
47. Turner JA (2010) Diagnosis and management of pre-eclampsia: an update. Int J Womens Health 2:327-37 CrossRef
48. Wallukat G, Neichel D, Nissen E, Homuth V, Luft FC (2003) Agonistic autoantibodies directed against the angiotensin II AT1 receptor in patients with preeclampsia. Can J Physiol Pharmacol 81:79-3 CrossRef
49. Walsh SK, English FA, Johns EJ, Kenny LC (2009) Plasma-mediated vascular dysfunction in the reduced uterine perfusion pressure model of preeclampsia: a microvascular characterization. Hypertension 54:345-51 CrossRef
50. Wang D, Ishimura R, Walia DS, Muller H, Dai G, Hunt JS, Lee NA, Lee JJ, Soares MJ (2000) Eosinophils are cellular targets of the novel uteroplacental heparin-binding cytokine decidual/trophoblast prolactin-related protein. J Endocrinol 167:15-8 CrossRef
51. Wedepohl S, Beceren-Braun F, Riese S, Buscher K, Enders S, Bernhard G, Kilian K, Blanchard V, Dernedde J, Tauber R (2012) L-selectin—a dynamic regulator of leukocyte migration. Eur J Cell Biol 91:257-64 CrossRef
52. Wiemers DO, Ain R, Ohboshi S, Soares MJ (2003) Migratory trophoblast cells express a newly identified member of the prolactin gene family. J Endocrinol 179:335-46 CrossRef
53. Winn VD, Gormley M, Paquet AC, Kjaer-Sorensen K, Kramer A, Rumer KK, Haimov-Kochman R, Yeh RF, Overgaard MT, Varki A, Oxvig C, Fisher SJ (2009) Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2. Endocrinology 150:452-62 CrossRef - 作者单位：Eric M. George (1)
Michael R. Garrett (2)
Joey P. Granger (1)
1. Departments of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N. State St., Jackson, MS, 39216, USA
2. Departments of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500?N. State St., Jackson, MS, 39216, USA - ISSN：1432-1777
文摘
Preeclampsia is a serious and common hypertensive complication of pregnancy, affecting ~5 to 8?% of pregnancies. The underlying cause of preeclampsia is believed to be placental ischemia, which causes secretion of pathogenic factors into the maternal circulation. While a number of these factors have been identified, it is likely that others remain to be elucidated. Here, we have utilized a relevant preclinical rodent model of placental ischemia-induced hypertension, the reduced uterine perfusion pressure (RUPP) model, to determine the effect of chronic placental ischemia on the underlying chorionic tissue and placental villi. Tissue from control and RUPP rats were isolated on gestational day 19 and mRNA from these tissues was subjected to microarray analysis to determine differential gene expression. At a statistical cutoff of p?<?0.05, some 2,557 genes were differentially regulated between the two groups. Interestingly, only a small subset (22) of these genes exhibited changes of greater than 50?% versus control, a large proportion of which were subsequently confirmed using qRT-PCR analysis. Network analysis indicated a strong effect on inflammatory pathways, including those involving NF-κB and inflammatory cytokines. Of the most differentially expressed genes, the predominant gene classes were extracellular remodeling proteins, pro-inflammatory proteins, and a coordinated upregulation of the prolactin genes. The functional implications of these novel factors are discussed.