Is boosting the immune system in sepsis appropriate?
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- 作者：Jean-Marc Cavaillon (1)
Damon Eisen (2) (3)
Djilalli Annane (4)
1. Unit Cytokines & Inflammation ; Institut Pasteur ; 28 rue Dr. Roux ; 75015 ; Paris ; France
2. Victorian Infectious Diseases Service ; Royal Melbourne Hospital ; 300 Grattan Street ; Parkville ; 3050 ; Victoria ; Australia
3. Department of Medicine ; Royal Melbourne Hospital ; University of Melbourne ; Victorian Infectious Diseases Service ; Royal Melbourne Hospital ; 300 Grattan Street ; Parkville ; 3050 ; Victoria ; Australia
4. Intensive Care Unit ; H么pital Raymond Poincar茅 ; 104 ; boulevard Raymond-Poincar茅 ; 92380 ; Garches ; France - 刊名：Critical Care
- 出版年：2014
- 出版时间：April 2014
- 年：2014
- 卷：18
- 期：2
- 全文大小：354 KB
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- 出版者：BioMed Central
- ISSN：1364-8535
文摘
A relative immunosuppression is observed in patients after sepsis, trauma, burns, or any severe insults. It is currently proposed that selected patients will benefit from treatment aimed at boosting their immune systems. However, the host immune response needs to be considered in context with pathogen-type, timing, and mainly tissue specificity. Indeed, the immune status of leukocytes is not universally decreased and their activated status in tissues contributes to organ failure. Accordingly, any new immune-stimulatory therapeutic intervention should take into consideration potentially deleterious effects in some situations.