Temporal dynamics of anxiety phenotypes in a dental pulp injury model
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- 作者：Lin Shang ; Tian-Le Xu ; Fei Li ; Jiansheng Su ; Wei-Guang Li
- 关键词：Dental pulp injury ; Pain ; Anxiety ; Social phobia ; Synaptic plasticity
- 刊名：Molecular Pain
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：11
- 期：1
- 全文大小：7,172 KB
- 刊物主题：Pain Medicine; Molecular Medicine;
- 出版者：BioMed Central
- ISSN：1744-8069
文摘
Background Accumulating clinical and preclinical evidence indicates that chronic pain is often comorbid with persistent low mood and anxiety. However, the mechanisms underlying pain-induced anxiety, such as its causality, temporal progression, and relevant neural networks are poorly understood, impeding the development of efficacious therapeutic approaches.