Are protein hubs faster folders? Exploration based on Escherichia coli proteome

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• 作者：Hong-Rui Xu ; Jun-Feng Cheng ; Xiao-Pan Hu ; Ying-Ying Chu ; Bin-Guang Ma
• 关键词：Protein interaction network ; Hub proteins ; Protein folding and binding ; Folding rate
• 刊名：Amino Acids
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：48
• 期：12
• 页码：2747-2753
• 全文大小：1,122 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Analytical Chemistry
  Biochemical Engineering
  Life Sciences
  Proteomics
  Neurobiology
  
• 出版者：Springer Wien
• ISSN：1438-2199
• 卷排序：48

文摘

Protein hubs in protein–protein interaction network are especially important due to their central roles in the entire network. Despite of their importance, the folding kinetics of hub proteins in comparison with non-hubs is still unknown. In this work, the folding rates for protein hubs and non-hubs were predicted and compared for the interactome of Escherichia coli K12, and the results showed that hub proteins fold faster than non-hub proteins. A possible explanation might be that protein hubs have more and fast-folding structural conformations than non-hubs, which leads to the notion of “hub of hubs” in the protein conformation space. It was found that the sequence and structure features relevant to protein folding rates are also different between hub and non-hub proteins. Moreover, the interacting proteins tend to have similar folding rates. These results gave insightful implications for understanding the interplay between the mechanisms of protein folding and interaction.