Mechanism of depression as a risk factor in the development of Alzheimer’s disease: the function of AQP4 and the glymphatic system
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- 作者：Maosheng Xia ; Li Yang ; Guangfeng Sun ; Shuang Qi ; Baoman Li
- 关键词：Depression ; Alzheimer’s disease ; Amyloid beta 42 ; Glymphatic pathway ; Chronic unpredictable mild stress
- 刊名：Psychopharmacology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：234
- 期：3
- 页码：365-379
- 全文大小：
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Neurosciences; Pharmacology/Toxicology; Psychiatry;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-2072
- 卷排序：234
文摘
BackgroundMany studies have indicated that a history of depression increases the risk of developing Alzheimer’s disease (AD); however, the potential pathogenestic mechanism by which depression functions as a high risk factor for AD remains unknown. Recently, a “cerebral lymphatic system” referred to as “glymphatic system” has been demonstrated to be responsible for neuronal extracellular waste protein clearance via a paravascular pathway. However, the function of glymphatic pathway has not been determined in depressive disorders.