Polysomnographic characteristics of daytime sleepiness in obstructive sleep apnea syndrome

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• 作者：Yuanfeng Sun (1) (2)
  Yuping Ning (2)
  Lili Huang (1)
  Fei Lei (1)
  Zhe Li (1)
  Guangyao Zhou (1)
  Xiangdong Tang (1)
  
• 关键词：Obstructive sleep apnea syndrome ; Daytime sleepiness ; Polysomnography ; Multiple sleep latency tests ; Epworth sleepiness scale
• 刊名：Sleep and Breathing
• 出版年：2012
• 出版时间：June 2012
• 年：2012
• 卷：16
• 期：2
• 页码：375-381
• 全文大小：132KB
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• 作者单位：Yuanfeng Sun (1) (2)
  Yuping Ning (2)
  Lili Huang (1)
  Fei Lei (1)
  Zhe Li (1)
  Guangyao Zhou (1)
  Xiangdong Tang (1)
  
  1. Sleep Medicine Center, Department of Psychiatry, Department of Otolaryngology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China
  2. Department of Neurology, Affiliated Guangzhou Brain Hospital of Guangzhou Medical College, Guangzhou, Guangdong, 510370, China
  

文摘

Purpose The study is intended to explore the nocturnal sleep determinants for excessive daytime sleepiness (EDS) in patients with obstructive sleep apnea syndrome (OSAS). Methods Consecutive patients (n--82) who had an apnea/hypopnea index (AHI) greater than 5 times per hour were used in this study. EDS (n--2) was considered present whenever the Epworth sleepiness scale (ESS) score was >10 and the multiple sleep latency test (MSLT) score was <5?min. Absence of EDS (no EDS, n--8) was determined in patients with an ESS score of <10 and a MSLT score of >10?min. Results Compared to no EDS patients, EDS patients exhibited (1) greater AHI and time length of SaO2 <95%, lower nocturnal SaO2 during separate rapid eye movement (REM) and NREM periods, and lower total mean and minimum SaO2 during total recording period; (2) shortened latency to sleep and to REM sleep, and increased total sleep time and sleep efficiency; and (3) increases in the brief arousal index and duration of sleep stage 1. In addition, stepwise logistic regression analysis showed that the arousal index, the time length of SaO2 <95%, and the latency to REM were independent predictors of EDS. Conclusions The results suggest that EDS in OSAS patients are characterized by the following aspects of nocturnal sleep: (1) severe sleep apnea/hypopnea and hypoxemia, (2) fragmented sleep, (3) low quality of sleep, and (4) high pressure of sleep drive.