Conservative management of corpus luteum haemorrhage in patients on anticoagulation: a report of three cases and review of literature

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• 作者：Avantika Gupta (1) (2)
  Sangeeta Gupta (1)
  Usha Manaktala (1)
  Madhavi Mathur Gupta (1)
  Vandana Solanki (1)
  
  1. Department of Obstetrics and Gynaecology ; Maulana Azad Medical College ; New Delhi ; India
  2. Department of Obstetrics and Gynaecology ; Maulana Azad Medical College ; House no. 93/94 ; Pocket-2 ; Sector 22 ; Rohini ; New Delhi ; 110086 ; India
  
• 关键词：Corpus luteum haemorrhage ; Warfarin ; Hemoperitoneum ; Conservative management
• 刊名：Archives of Gynecology and Obstetrics
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：291
• 期：2
• 页码：427-431
• 全文大小：160 KB
• 参考文献：1. Jain KA (2002) Sonographic spectrum of hemorrhagic ovarian cysts. J Ultrasound Med 21:879鈥?86
  2. Korver T, Klipping C, Heger-Mahn D, Duijkers I, Osta G, Dieben T (2005) Maintenance of ovulation inhibition with the 75-microg desogestrel-only contraceptive pill (Cerazette) after scheduled 12-h delays in tablet intake. Contraception 71(1):8鈥?3 CrossRef
  3. Beyth RJ, Quinn LM, Landefeld CS (1998) Prospective evaluation of an index for predicting the risk of major bleeding in outpatients treated with Warfarin. Am J Med 105(2):91鈥?9 CrossRef
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  5. Faraj R, Martindale E, Hill S (2008) Massive ovarian cyst haemorrhage with haemoperitoneum as a complication of long-term anticoagulation. J Obstet Gynaecol 28(2):250鈥?51 CrossRef
  6. Tresch DD, Halverson G, Blick M, Keelan MH Jr (1978) Ovarian (corpus luteum) hemorrhage during anticoagulation therapy. Ann Intern Med 88:642鈥?46 CrossRef
  7. Palareti G, Leali N, Coccheri S, Poggi M, Manotti C, D鈥橝ngelo A, Pengo V, Erba N, Moia M, Ciavarella N, Devoto G, Berrettini M, Musolesi S (1996) Bleeding complications of oral anticoagulant treatment: an inception-cohort, prospective collaborative study (ISCOAT). Italian study on complications of oral anticoagulant therapy. Lancet 348(9025):423鈥?28 CrossRef
  8. Jamal A, Mesdaghinia S (2002) Ruptured corpus luteum cysts and anticoagulant therapy. Int J Gynaecol Obstet 76:319鈥?20 CrossRef
  9. Hallatt JG, Steele CH Jr, Snyder M (1984) Ruptured corpus luteum with hemoperitoneum: a study of 173 surgical cases. Am J Obstet Gynecol 149(1):5鈥? CrossRef
  10. Hill JA, Kassam SH (1984) Ovarian hemorrhage in ovulating women receiving anticoagulant therapy鈥攁 report of two cases. J Reprod Med 29(3):205鈥?08
  11. Peters WA 3rd, Thiagarajah S, Thornton WN Jr (1979) Ovarian hemorrhage in patients receiving anticoagulant therapy. J Reprod Med 22(2):82鈥?6
  12. Semchyshyn S, Zuspan FP (1978) Ovarian hemorrhage due to anticoagulants. Am J Obstet Gynecol 131(8):838鈥?44
  13. Yamakani LY, de Araujo DB, Silva CA, Baracat EC, Carvalho JF (2011) Severe hemorrhagic corpus luteum complicating anticoagulation in antiphospholipid syndrome. Lupus 20(5):523鈥?26 CrossRef
  14. Itskovitz J, Brandes JM, Urbach J, Fisher M (1967) Ovarian hematoma and hemoperitoneum complicating anticoagulant therapy. Int Surg 4:533鈥?34
  15. Department of Reproductive Health, World Health Organisation (2009). In: Medical eligibility criteria for contraceptive use, 4th edn. WHO, Geneva, Switzerland. http://whqlibdoc.who.int/publications/2010/9789241563888_eng.pdf
  16. Sonmezer M, Atabekoglu C, Cengiz B, Dokmeci F, Cengiz SD (2005) Depot-medroxyprogesterone acetate in anticoagulated patients with previous hemorrhagic corpus luteum. Eur J Contracept Reprod Health Care 10:9鈥?4 CrossRef
  17. Ulrich U, Rossmanith WG (1994) Management of peritoneal hemorrhage due to follicle rupture under anticoagulation therapy. J Endocrinol Invest 17:351鈥?53 CrossRef
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gynecology
  Obstetrics and Perinatology
  Endocrinology
  Human Genetics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0711

文摘

Introduction Severe bleeding into the peritoneal cavity from a ruptured corpus luteum cyst is a rare complication in women receiving anticoagulation therapy. Surgical management has been a traditional approach in managing corpus luteum haemorrhage, however, conservative management is now dominating the trend in carefully selected patients. Material and Methods We report here a series of three cases of corpus luteum haemorrhage with variable presentation. Conservative management was started in all the three patients and was successful in two cases. Finding a safe, effective, and acceptable method to inhibit ovulation in women on anticoagulation for mechanical heart valve is a challenge. All three patients were prescribed cyclical oral Desogestrel for long-term ovulation suppression. Conclusion Selected patients with haemorrhage secondary to deranged coagulation can undergo conservative management in consultation with cardiologist and hematologist.