Microvesicles derived from hypoxia/reoxygenation-treated human umbilical vein endothelial cells promote apoptosis and oxidative stress in H9c2 cardiomyocytes
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- 作者：Qi Zhang ; Man Shang ; Mengxiao Zhang ; Yao Wang ; Yan Chen ; Yanna Wu…
- 关键词：Endothelial microvesicles ; Oxidative stress ; Apoptosis ; H9c2 cardiomyocytes ; Hypoxia/reoxygenation
- 刊名：BMC Cell Biology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：17
- 期：1
- 全文大小：3036KB
- 刊物主题：Cell Biology; Biological Microscopy; Life Sciences, general;
- 出版者：BioMed Central
- ISSN：1471-2121
- 卷排序：17
文摘
BackgroundVascular endothelial dysfunction is the closely related determinant of ischemic heart disease (IHD). Endothelial dysfunction and ischemia/reperfusion injury (IRI) have been associated with an increase in microvesicles (MVs) in vivo. However, the potential contribution of endothelial microvesicles (EMVs) to myocardial damage is unclear. Here we aimed to investigate the role of EMVs derived from hypoxia/reoxygenation (H/R) -treated human umbilical vein endothelial cells (HUVECs) on cultured H9c2 cardiomyocytes.