The main rhinovirus respiratory tract adhesion site (ICAM-1) is upregulated in smokers and patients with chronic airflow limitation (CAL)
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- 作者：Shakti Dhar Shukla ; Malik Quasir Mahmood ; Steven Weston…
- 关键词：Intercellular adhesion molecule ; 1 ; Human rhinovirus ; Epithelial adhesion ; Chronic obstructive pulmonary disease ; Chronic airflow limitation
- 刊名：Respiratory Research
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：18
- 期：1
- 全文大小：1585KB
- 刊物主题：Pneumology/Respiratory System;
- 出版者：BioMed Central
- ISSN：1465-993X
- 卷排序：18
文摘
BackgroundICAM-1 is a major receptor for ~60% of human rhinoviruses, and non-typeable Haemophilus influenzae, two major pathogens in COPD. Increased cell-surface expression of ICAM-1 in response to tobacco smoke exposure has been suggested. We have investigated epithelial ICAM-1 expression in both the large and small airways, and lung parenchyma in smoking-related chronic airflow limitation (CAL) patients.