Magnetic resonance imaging in early rheumatoid arthritis: a multicenter, prospective study

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• 作者：Ru Li ; Xia Liu ; Hua Ye ; Hai-Hong Yao ; Jia-Long Guo ; Guang-Tao Li…
• 关键词：Early rheumatoid arthritis ; Magnetic resonance imaging ; Synovitis
• 刊名：Clinical Rheumatology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：35
• 期：2
• 页码：303-308
• 全文大小：398 KB
• 参考文献：1.Boers M (2003) Understanding the window of opportunity concept in early rheumatoid arthritis. Arthritis Rheum 48:1771–1774CrossRef PubMed
  2.Arnett FC, Edworthy SM, Bloch DA et al (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315–324CrossRef PubMed
  3.van der Linden MP, Knevel R, Huizinga TW et al (2011) Classification of rheumatoid arthritis: comparison of the 1987 American College of Rheumatology criteria and the 2010 American College of Rheumatology/European League Against Rheumatism criteria. Arthritis Rheum 63:37–42CrossRef PubMed
  4.Kosta PE, Voulgari PV, Zikou AK, Drosos AA, Argyropoulou MI (2011) The usefulness of magnetic resonance imaging of the hand and wrist in very early rheumatoid arthritis. Arthritis Res Ther 13:R84PubMedCentral CrossRef PubMed
  5.Olech E, Crues JV 3rd, Yocum DE, Merrill JT (2010) Bone marrow edema is the most specific finding for rheumatoid arthritis (RA) on noncontrast magnetic resonance imaging of the hands and wrists: a comparison of patients with RA and healthy controls. J Rheumatol 37:265–274CrossRef PubMed
  6.Bøyesen P, Haavardsholm EA, Ostergaard M, van der Heijde D, Sesseng S, Kvien TK (2011) MRI in early rheumatoid arthritis: synovitis and bone marrow oedema are independent predictors of subsequent radiographic progression. Ann Rheum Dis 70:428–433CrossRef PubMed
  7.Suter LG, Fraenkel L, Braithwaite RS (2011) Role of magnetic resonance imaging in the diagnosis and prognosis of rheumatoid arthritis. Arthritis Care Res (Hoboken) 63:675–688CrossRef
  8.Østergaard M, Edmonds J, McQueen F et al (2005) An introduction to the EULAR-OMERACT rheumatoid arthritis MRI reference image atlas. Ann Rheum Dis 64(Suppl 1):i3–i7PubMedCentral CrossRef PubMed
  9.Haavardsholm EA, Østergaard M, Ejbjerg BJ, Kvan NP, Kvien TK (2007) Introduction of a novel magnetic resonance imaging tenosynovitis score for rheumatoid arthritis: reliability in a multireader longitudinal study. Ann Rheum Dis 66:1216–1220PubMedCentral CrossRef PubMed
  10.Tamai M, Kawakami A, Uetani M et al (2006) Early prediction of rheumatoid arthritis by serological variables and magnetic resonance imaging of the wrists and finger joints: results from prospective clinical examination. Ann Rheum Dis 65:134–135PubMedCentral CrossRef PubMed
  11.Baan H, Bezooijen R, Avenarius JK, Dubbeldam R, Drossaers-Bakker WK, van de Laar MA (2011) Magnetic resonance imaging of the rheumatic foot according to the RAMRIS system is reliable. J Rheumatol 38:1003–1008CrossRef PubMed
  12.Boutry N, Hachulla E, Flipo RM, Cortet B, Cotten A (2005) MR imaging findings in hands in early rheumatoid arthritis: comparison with those in systemic lupus erythematosus and primary Sjogren’s syndrome. Radiology 236:593–600CrossRef PubMed
  13.Duer-Jensen A, Hørslev-Petersen K, Hetland ML et al (2011) Bone edema on magnetic resonance imaging is an independent predictor of rheumatoid arthritis development in patients with early undifferentiated arthritis. Arthritis Rheum 63:2192–2202CrossRef PubMed
  
• 作者单位：Ru Li (1)
  Xia Liu (2)
  Hua Ye (1)
  Hai-Hong Yao (1)
  Jia-Long Guo (3)
  Guang-Tao Li (4)
  Xing-Fu Li (5)
  Yu Xue (6)
  Jin-Xia Zhao (7)
  Fei Gu (8)
  Qing-Hua Zou (9)
  Li-Na Chen (10)
  Li-Qi Bi (3)
  Zhuo-Li Zhang (4)
  He-Jian Zou (6)
  Xiang-Yuan Liu (7)
  Ling-Yun Sun (8)
  Yong-Fei Fang (9)
  Ping Zhu (10)
  Yin Su (1)
  Zhan-Guo Li (1)
  
  1. Department of Rheumatology and Immunology, Peking University People’s Hospital, 11 Xizhimen South Street, Beijing, 100044, China
  2. Department of Radiology, Peking University People’s Hospital, Beijing, China
  3. Department of Rheumatology and Immunology, Jilin University China-Japan Union Hospital, Changchun, China
  4. Department of Rheumatology and Immunology, Peking University First Hospital, Beijing, China
  5. Department of Rheumatology and Immunology, Shandong University Qilu Hospital, Jinan, China
  6. Department of Rheumatology and Immunology, Fudan University Huashan Hospital, Shanghai, China
  7. Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China
  8. Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
  9. Department of Rheumatology and Immunology, Third Military Medical University Southwest Hospital, Chongqing, China
  10. Department of Clinical Immunology, Fourth Military Medical University Xijing Hospital, Xi’an, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Rheumatology
  
• 出版者：Springer London
• ISSN：1434-9949

文摘

To identify the magnetic resonance imaging (MRI) features of hands and wrists in early rheumatoid arthritis (RA). A total of 129 early arthritis patients (≤1 year) were enrolled in the study. At presentation, MRI of the hands was performed, with clinical and laboratory analyses. After a 1-year follow-up, clinical diagnosis of early RA or non-RA was confirmed by two rheumatologists. The characteristics of MRI variables at baseline in RA patients not fulfilling ACR 1987 criteria [RA-87(−)] were compared with those fulfilling ACR1987 criteria [RA-87(+)] and non-RA. In the 129 early arthritis patients, 90 were diagnosed with RA in a 1-year follow-up. There were 47.8 % (43/90) of the RA patients not fulfilling ACR 1987 criteria [RA-87(−)]. The scores of synovitis in RA-87(−) patients were similar with those in RA-87(+) [Synovitis score, 14.0 (IQR, 4.0–25.0) vs. 14.0 (IQR, 10.0–25.0), p > 0.05]. Compared with those in non-RA, RA-87(−) patients had higher synovitis scores and occurrence of synovitis in proximal interphalangeal (PIP) joints [synovitis score, 14.0 (IQR, 4.0–25.0) vs. 6.0 (IQR, 2.0–14.5), p = 0.046; occurrence of PIP synovitis: 53.5 vs. 27.3 %, p = 0.02]. There was no significant difference of bone marrow edema, bone erosion, and tenosynovitis between RA-87(−) and non-RA. Synovitis in PIP joints was independent predictor for RA-87(−) [OR, 3.1 (95 %CI 1.2–8.1)]. High synovitis scores and synovitis in PIP joints on MRI were important in early RA, especially those not fulfilling ACR 1987 criteria. Keywords Early rheumatoid arthritis Magnetic resonance imaging Synovitis