The human RNA surveillance factor UPF1 regulates tumorigenesis by targeting Smad7 in hepatocellular carcinoma

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• 作者：Lei Chang ; Cuicui Li ; Tao Guo ; Haitao Wang…
• 关键词：Hepatocellular carcinoma ; UPF1 ; Smad7 ; Hypermethylation
• 刊名：Journal of Experimental & Clinical Cancer Research
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：35
• 期：1
• 全文大小：2,353 KB
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• 作者单位：Lei Chang (1)
  Cuicui Li (2)
  Tao Guo (1)
  Haitao Wang (1)
  Weijie Ma (1)
  Yufeng Yuan (1)
  Quanyan Liu (1)
  Qifa Ye (2)
  Zhisu Liu (1)
  
  1. Department of General Surgery, Research Center of Digestive Diseases, Zhongnan Hospital of Wuhan University, Donghu Road 169, Wuhan, 430071, China
  2. Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation Donghu Road 169, Wuhan, 430071, China
  
• 刊物主题：Oncology; Cancer Research;
• 出版者：BioMed Central
• ISSN：1756-9966

文摘

Background In spite of progress in diagnostics and treatment of Hepatocellular Carcinoma (HCC), its prognosis remains poor, and improved treatment strategies for HCC require detailed understanding of the underlying mechanism. In this investigation we studied the role of Up-frameshift 1 (UPF1) in the tumorigenesis of HCC.