Hemodynamic effects of intraoperative anesthetics administration in photothrombotic stroke model: a study using laser speckle imaging
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- 作者：Hongyang Lu ; Yao Li ; Bin Bo ; Lu Yuan ; Xiaodan Lu ; Hangdao Li…
- 关键词：Laser speckle imaging ; Photothrombotic stroke model ; Hemodynamic effect ; Anesthetics
- 刊名：BMC Neuroscience
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：18
- 期：1
- 全文大小：2038KB
- 刊物主题：Neurosciences; Neurobiology; Animal Models;
- 出版者：BioMed Central
- ISSN：1471-2202
- 卷排序：18
文摘
BackgroundPrevious neuroimaging studies have shown the hemodynamic effect of either preconditioning or postconditioning anesthesia in ischemic stroke model. However, the anesthetic effect in hemodynamics during and immediately after the stroke modeling surgery remains unknown due to the lack of appropriate anesthesia-free stroke model and intraoperative imaging technology. In the present study, we utilized our recently developed photothrombotic model of focal cerebral ischemia in conscious and freely moving rats, and investigated transient hemodynamic changes with or without isoflurane administration. Laser speckle imaging was applied to acquire real-time two-dimensional full-field cerebral blood flow (CBF) information throughout the surgical operations and early after.