Comparative study of oxidative stress induced by sand flower and schistose nanosized layered double hydroxides in N2a cells

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• 作者：Yu Lu ; Biao Yan ; Xudong Liu ; Yuchao Zhang ; Shibi Zeng ; Hao Hu…
• 关键词：magnesium ; aluminum layered double hydroxide ; mouse neuroblastoma cell ; oxidative stress ; reactive oxygen species
• 刊名：Frontiers in Biology
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：10
• 期：3
• 页码：279-286
• 全文大小：908 KB
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• 作者单位：Yu Lu (1)
  Biao Yan (1)
  Xudong Liu (1)
  Yuchao Zhang (1)
  Shibi Zeng (2)
  Hao Hu (2)
  Rong Xiang (3)
  Yu Xu (3)
  Ying Yu (2)
  Xu Yang (1)
  
  1. Hubei Key Laboratory of Genetic Regulation and Integrative Biology College of Life Science, Central China Normal University, Wuhan, 430079, China
  2. Institute of Nanoscience and Nanotechnology, Central China Normal University, Wuhan, 430079, China
  3. Department of Otolaryngology, Head & Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China
  
• 刊物主题：Proteomics; Neurobiology; Genetics and Population Dynamics; Developmental Biology; Biochemistry, general; Cell Biology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1674-7992

文摘

Magnesium-aluminum layered double hydroxide (Mg/Al-LDH) nanoparticles have strong potential application as drug delivery systems because of their low toxicity and suitable biocompatibility. However, few studies have described the morphological effects of these hydroxides on nerve cells. The present study compares the oxidative stress induced by different concentrations (i.e., 0, 50, 100, 200, 400, and 800 μg/mL) of sand flower and flake nano-Mg/Al-LDHs in mouse neuroblastoma cells (N2a) when these cells were exposed for 24 and 48 h. Cell viability was detected by MTT assay, and production of reactive oxygen species (ROS), glutathione (GSH), and malondialdehyde (MDA) were monitored to evaluate oxidative damage. Results suggested that sand flower nano-LDHs, at the appropriate concentrations (less than 200 μg/mL), especially those of about 100-00 nm in size, induce no harmful effects on N2a cells.