Association between variants of EXT2 and type 2 diabetes: a replication and meta-analysis

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• 作者：Lei Liu (1)
  Xu Yang (1)
  Haoran Wang (1)
  Guanglin Cui (1)
  Yujun Xu (1)
  Peihua Wang (1)
  Gang Yuan (1)
  Xiaojing Wang (2)
  Hu Ding (1)
  Dao Wen Wang (1)
  
• 刊名：Human Genetics
• 出版年：2013
• 出版时间：February 2013
• 年：2013
• 卷：132
• 期：2
• 页码：139-145
• 全文大小：283KB
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• 作者单位：Lei Liu (1)
  Xu Yang (1)
  Haoran Wang (1)
  Guanglin Cui (1)
  Yujun Xu (1)
  Peihua Wang (1)
  Gang Yuan (1)
  Xiaojing Wang (2)
  Hu Ding (1)
  Dao Wen Wang (1)
  
  1. Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095# Jiefang Ave., 430030, Wuhan, People’s Republic of China
  2. School of Dental Medicine, Center for Craniofacial and Dental Genetics, University of Pittsburgh, Pittsburgh, PA, 15219, USA
  
• ISSN：1432-1203

文摘

Recent publications have found an association between variants of exostosin 2 (EXT2) gene and the risk of type 2 diabetes in some population but not in others. In an attempt to address these inconsistencies, we investigated EXT2 variants in two independent cohorts, and conducted a literature-based meta-analysis. Through regression model, we assessed the relationship between the EXT2 single nucleotide polymorphisms (SNPs) (rs3740878, rs11037909 and rs1113132) and the risk of type 2 diabetes in Han Chinese population, including a total of 2,533 cases and 2,643 controls. We combined our data with that from previously published studies and performed a meta-analysis to evaluate the effect size of the gene. Consistent with some studies, we found marginal association for the rs3740878 (OR?=?1.07, 95?% CI?=?0.99, 1.16, p?=?0.09), rs11037909 (OR?=?1.07, 95?% CI?=?0.99, 1.16, p?=?0.08), and rs1113132 (OR?=?1.08, 95?% CI?=?1.00, 1.17, p?=?0.06) in our 2 cohorts. Meta-analysis, comprising 9,224 type 2 diabetes and 10,484 controls, revealed that three SNPs (rs3740878, rs11037909 and rs1113132) in EXT2 were significantly associated with type 2 diabetes (ORs range from 1.06 to 1.07, p?=?0.038, p?=?0.008 and p?=?0.005, respectively). Variation in the EXT2 locus appears to be associated with a small increase in the risk of type 2 diabetes. However, well-designed prospective studies with larger sample size and more ethnic groups are needed to further validate the results.