Histopathologic and biochemical study of the effect of saffron extract on gentamicin-induced nephrotoxicity in rats
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- 作者：Amin Derakhshanfar ; Mahdi Hashempour Sadeghian…
- 关键词：Gentamicin ; Renal failure ; Saffron ; Nephrotoxicity
- 刊名：Comparative Clinical Pathology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：24
- 期：6
- 页码：1347-1351
- 全文大小：2,034 KB
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Mahdi Hashempour Sadeghian (4)
Narjes Abbasabadi (5)
Mohammad Hosein Imanian (6)
1. Diagnostic Laboratory Sciences and Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2. Basic Sciences in Infection Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3. Center of Comparative & Experimental Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4. Department of Basic Science, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran
5. Faculty of Veterinary Medicine, Shahid Bahonar University, Kerman, Iran
6. Faculty of Veterinary Medicine, Islamic Azad university, Kazeroon, Iran - 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Pathology
Hematology
Oncology - 出版者：Springer London
- ISSN：1618-565X
文摘
Aminoglycoside antibiotic, gentamicin, is widely used against gram-negative bacteria; however, its clinical use is limited due to its nephrotoxicity. Saffron extract has been previously used to decrease oxidative stress induced by ischemia-reperfusion. Here, we studied the effect of aqueous saffron extract on gentamicin toxicity. Twenty-eight male Wister rats were divided randomly into 4 equal groups and were injected with gentamicin (100 mg/kg I.M.), aqueous saffron extract (5 mg/kg I.P.), combination of thereof, and saline (1 ml I.M.). All treatments were done for ten consecutive days. Gentamicin-administered rats showed increase in serum urea and creatinine and urinary Gamma-glutamyltranspeptidase (GGT) together with acute tubular necrosis while saffron co-administered rats revealed lower concentration of urinary GGT and serum urea and creatinine and lower degree of necrosis. Rats treated with saffron did not show any change in biochemical indices compared to control rats but they showed severe congestion in their kidney cortex. Our study has shown the protective effect of saffron on gentamicin-induced nephrotoxicity in rats. Keyword Gentamicin Renal failure Saffron Nephrotoxicity