Overestimation of the risk of progression to end-stage renal disease in the poor prognosis-group according to the 2002 Japanese histological classification for immunoglobulin A nephropathy
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- 作者：Yoichi Miyazaki (1)
Tetsuya Kawamura (1)
Kensuke Joh (2)
Hideo Okonogi (1)
Kentaro Koike (1)
Yasunori Utsunomiya (1)
Makoto Ogura (1)
Masato Matsushima (3)
Mitsuhiro Yoshimura (4)
Satoshi Horikoshi (5)
Yusuke Suzuki (5)
Akira Furusu (6)
Takashi Yasuda (7)
Sayuri Shirai (7)
Takanori Shibata (8)
Masayuki Endoh (9)
Motoshi Hattori (10)
Yuko Akioka (10)
Ritsuko Katafuti (11)
Akinori Hashiguchi (12)
Kenjiro Kimura (7)
Seiichi Matsuo (13)
Yasuhiko Tomino (5) - 关键词：Current histological classification ; IgA nephropathy classification ; Tuft adhesion ; Multicenter ; Case–control study ; EGFR decline
- 刊名：Clinical and Experimental Nephrology
- 出版年：2014
- 出版时间：June 2014
- 年：2014
- 卷：18
- 期：3
- 页码：475-480
- 全文大小：
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12. Working Group of the International IgA Nephropathy Network and the Renal Pathology Society, Cattran DC, Coppo R, Cook HT, Feehally J, Roberts IS, Troyanov S, et al. The Oxford classification of IgA nephrolaty: rationale, clinicopathological correlations, and classification. Kidney Int. 2009; 76:534-5.
13. Hotta O, Miyazaki M, Furuta T, Tomioka S, Chiba S, Horigome I, et al. Tonsillectomy and steroid pulse therapy significantly impact on clinical remission in patients with IgA nephropathy. Am J Kidney Dis. 2001;38:736-3. CrossRef
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15. Komatsu H, Fujimoto S, Hara S, Sato Y, Yamada K, Kitamura K. Effect of tonsillectomy plus steroid pulse therapy on clinical remission of IgA nephropathy: a controlled study. Clin J Am Soc Nephrol. 2008;3:1301-. CrossRef
16. Hirano K, Kawamura T, Tsuboi N, Okonogi H, Miyazaki Y, Ikeda M et al. The predictive value of attenuated proteinuria at 1?year after steroid therapy for renal survival in patients with IgA nephropathy. Clin Exp Nephrol (in press).
17. Miura N, Imai H, Kikuchi S, Hayashi S, Endoh M, Kawamura T, et al. Tonsillectomy and steroid pulse (TSP) therapy for patients with IgA nephropathy: a nationwide survey of TSP therapy in Japan and an analysis of the predictive factors for resistance to TSP therapy. Clin Exp Nephrol. 2009;13:460-. CrossRef
18. Matsuzaki K, Suzuki Y, Nakata J, Sakamoto N, Horikoshi S, Kawamura T, et al. Nationwide survey on current treatments for IgA nephropathy in Japan. Clin Exp Nephrol. (in press). - 作者单位：Yoichi Miyazaki (1)
Tetsuya Kawamura (1)
Kensuke Joh (2)
Hideo Okonogi (1)
Kentaro Koike (1)
Yasunori Utsunomiya (1)
Makoto Ogura (1)
Masato Matsushima (3)
Mitsuhiro Yoshimura (4)
Satoshi Horikoshi (5)
Yusuke Suzuki (5)
Akira Furusu (6)
Takashi Yasuda (7)
Sayuri Shirai (7)
Takanori Shibata (8)
Masayuki Endoh (9)
Motoshi Hattori (10)
Yuko Akioka (10)
Ritsuko Katafuti (11)
Akinori Hashiguchi (12)
Kenjiro Kimura (7)
Seiichi Matsuo (13)
Yasuhiko Tomino (5)
1. Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-Ku, Tokyo, 105-0003, Japan
2. Department of Pathology, Sendai Shakaihoken Hospital, Sendai, Japan
3. Division of Clinical Epidemiology, General Research Centre of Medicine, Jikei University School of Medicine, Tokyo, Japan
4. Department of Internal Medicine, Kanazawa Medical Centre, Kanazawa, Japan
5. Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan
6. Second Department of Internal Medicine, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki, Japan
7. Division of Kidney and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan
8. Division of Nephrology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan
9. Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan
10. Department of Pediatric Nephrology, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan
11. Division of Internal Medicine, National Fukuoka-Higashi Medical Center, Fukuoka, Japan
12. Department of Pathology, Keio University School of Medicine, Tokyo, Japan
13. Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, University of Nagoya, Nagoya, Japan - ISSN：1437-7799
文摘
Background The current (2012) histological classification of immunoglobulin A nephropathy was established using a case–control study of 287 patients. However, the risk of progression to end-stage renal disease (ESRD) has not been validated for the previous (2002) classification. This study aimed to determine whether the previous classification could identify the risk of long-term renal outcome through re-analysis of the 2012 cohort. Methods On the basis of the 2002 classification, namely ‘good prognosis- ‘relatively good prognosis- ‘relatively poor prognosis- and ‘poor prognosis- we examined the clinical data at the time of biopsy, the correlation between the 2002 classification and long-term renal outcomes, and a patient-by-patient correlation between the 2002 and 2012 classification systems. This was performed by analyzing samples from the 287 patients used to establish the 2012 classification. Results The rate of decline of estimated glomerular filtration rate was greater and the odds ratio of progression to ESRD was higher in the ‘poor prognosis-group. In contrast, the odds ratio for renal death was comparable between the groups described as ‘relatively poor prognosis-and ‘relatively good prognosis-in the 2002 classification. Many patients in the 2002 classification were classified with a lower histological grade in the current classification, but none were classified with a higher grade. Conclusions The 2002 classification could also identify the risk of progression to ESRD. However, it was overestimated for patients in the ‘poor prognosis-group in the 2002 classification, as that group included patients with milder histological damage.