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Are cases with tau pathology occurring in the absence of Aβ deposits part of the AD-related pathological process?
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  • 作者:Heiko Braak (1)
    Kelly Del Tredici (1)
  • 刊名:Acta Neuropathologica
  • 出版年:2014
  • 出版时间:December 2014
  • 年:2014
  • 卷:128
  • 期:6
  • 页码:767-772
  • 全文大小:1,130 KB
  • 参考文献:1. Braak H, Braak E (1991) Neuropathological staging of Alzheimer-related changes. Acta Neuropathol 82:239-59 CrossRef
    2. Braak H, Braak E (1992) The human entorhinal cortex: normal morphology and lamina-specific pathology in various diseases. Neurosci Res 15:6-1 CrossRef
    3. Braak H, Del Tredici K (2011) The pathological process underlying Alzheimer’s disease in individuals under thirty. Acta Neuropathol 121:171-81 CrossRef
    4. Braak H, Del Tredici K (2015) Neuroanatomy and pathology of sporadic Alzheimer’s disease. Advances in Anatomy Embryology and Cell Biology, Springer http://www.springer.com/biomed/neuroscience/book/978-3-319-12678-4
    5. Braak H, Thal DR, Ghebremedhin E et al (2011) Stages of the pathological process in Alzheimer disease: age categories from 1 to 100 years. J Neuropathol Exp Neurol 70:960-69 CrossRef
    6. Braak H, Zetterberg H, Del Tredici K et al (2013) Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid. Acta Neuropathol 126:631-41 CrossRef
    7. Chételat G, Fouquet M (2013) Neuroimaging biomarkers for Alzheimer’s disease in asymptomatic APOEe carriers. Rev Neurol 169:729-36 CrossRef
    8. Crary JF, Trojanowski JQ, Schneider JA et al (2014) Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathol. doi:10.1007/s00401-014-1349-0
    9. Ferrer I (2012) Defining Alzheimer as a common age-related neurodegenerative process not inevitably leading to dementia. Prog Neurobiol 97:38-1 CrossRef
    10. Fodero-Tavoletti MT, Furumoto S, Taylor L et al (2014) Assessing THK523 selectivity for tau deposits in Alzheimer’s disease and non-Alzheimer’s disease tauopathies. Alzheimers Res Ther 6:11-1 CrossRef
    11. Ghebremedhin E, Schultz C, Braak E et al (1998) High frequency of apolipoprotein E ε4 allele in young individuals with very mild Alzheimer’s disease-related neurofibrillary changes. Exp Neurol 153:152-55 CrossRef
    12. Goedert M, Falcon B, Clavaguera F et al (2014) Prion-like mechanisms in the pathogenesis of tauopathies and synucleinopathies. Curr Neurol Neurosci Rep 14:495 CrossRef
    13. Jagust WJ, Landau SM, Alzheimer’s Disease Neuroimaging Initiative (2012) Apolipoprotein E, not fibrillary β-amyloid, reduces cerebral glucose metabolism in normal aging. J Neurosci 32:18227-8233 CrossRef
    14. Kuninaka N, Kawaguchi M, Ogawa M et al (2014) Simplification of the Gallyas silver method. Neuropathology. doi:10.1111/neup.12144
    15. Montine TJ, Phelps CH, Beach TG et al (2012) National Institute on Aging-Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach. Acta Neuropathol 123:1-1 CrossRef
    16. Okamura N, Furumoto S, Harada R et al (2013) Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease. J Nucl Med 54:1420-427 CrossRef
    17. Perani D (2014) FDG-PET and amyloid-PET imaging: the diverging paths. Curr Opin Neurol 27:405-13 CrossRef
  • 作者单位:Heiko Braak (1)
    Kelly Del Tredici (1)

    1. Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Helmholtzstrasse 8/1, 89081, Ulm, Germany
  • ISSN:1432-0533
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