Helicobacter Pylori Infection: Diagnostic Strategies in Primary Diagnosis and After Therapy

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• 作者：Nathan S. S. Atkinson ; Barbara Braden
• 关键词：Helicobacter pylori infection ; Endoscopy ; Histology ; Urea breath test ; Stool antigen test ; Rapid urease test ; Serology ; Polymerase chain reaction ; Eradication
• 刊名：Digestive Diseases and Sciences
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：61
• 期：1
• 页码：19-24
• 全文大小：391 KB
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• 作者单位：Nathan S. S. Atkinson (1)
  Barbara Braden (1)
  
  1. Translational Gastroenterology Unit, Oxford University Hospitals NHS Trust, Headley Way, Oxford, OX3 9DU, UK
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gastroenterology
  Hepatology
  Oncology
  Transplant Surgery
  Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-2568

文摘

Accurate diagnosis of Helicobacter pylori infection pre- and post-treatment is mandatory in the current era of decreasing prevalence and increasing antibiotic resistance. The diagnostic performance of most tests is poorer in clinical situations with low bacterial density which is seen in conditions such as atrophic gastritis or intake of antisecretory and antibiotic medications. Noninvasive tests require less cost and resource but provide excellent accuracy; however, endoscopy with testing of gastric biopsy specimens is indicated where alarming symptoms are present or antibiotic susceptibility testing by culture is desired. Newer modalities such as polymerase chain reaction testing provide additional virulence and antibiotic sensitivity profiling. This article outlines new developments and the key parameters of each test, as careful selection of test modality within the clinical context is required for adequate management of infected symptomatic patients.