An unusual finding of massive pulmonary embolism in a patient during treatment with high-dose ibuprofen

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• 作者：Franca Bilora ; Angelo Adamo ; Fabio Pomerri…
• 关键词：Non ; steroidal anti ; inflammatory ; Venous thromboembolism ; Pulmonary embolism ; Ibuprofen ; Adverse effects
• 刊名：Aging Clinical and Experimental Research
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：28
• 期：1
• 页码：167-168
• 全文大小：393 KB
• 参考文献：1.Kaufman DW, Kelly JP, Rosenberg L et al (2002) Recent patterns of medication used in the ambulatory adult population of the United States: the Slone survey. JAMA 28:7337–7344
  2.Trelle S, Reichenbach S, Wandel S et al (2011) Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis. BMJ 342:c7086PubMedCentral CrossRef PubMed
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• 作者单位：Franca Bilora (1)
  Angelo Adamo (1)
  Fabio Pomerri (2)
  Paolo Prandoni (1)
  
  1. Internal Medicine, Coagulation Section, Cardiovascular Science Department, Padua University, Via Giustiniani, 2, 35128, Padua, Italy
  2. Internal Medicine Department (DIMED), Radiology Institute, Padua University, Padua, Italy
  
• 刊物主题：Geriatrics/Gerontology;
• 出版者：Springer International Publishing
• ISSN：1720-8319

文摘

Non-steroidal anti-inflammatory drugs have been associated with an increased risk of venous thromboembolism. We report for the first time, the case of a patient who developed massive pulmonary embolism after a long period of treatment with high doses of ibuprofen. A 65-year-old woman was admitted with severe dyspnea while on treatment with high doses of ibuprofen for diffuse spine pain due to arthrosis. A spiral computed tomography showed a massive pulmonary embolism. No other explanation for the thromboembolic disorder was found. She was successfully treated with therapeutic doses of low-molecular-weight heparin followed by rivaroxaban. Ibuprofen was discontinued and replaced by tramadol. High-dose ibuprofen is likely to have accounted for the life-threatening thromboembolic disorder. Keywords Non-steroidal anti-inflammatory Venous thromboembolism Pulmonary embolism Ibuprofen Adverse effects