Behavior of soluble HLA-A, -B, -C and HLA-G molecules in patients with chronic hepatitis C virus infection undergoing pegylated interferon-α and ribavirin treatment: potential role as markers of response to antiviral therapy

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• 作者：Giuseppe Murdaca ; Paola Contini ; Paola Cagnati…
• 关键词：Soluble HLA ; HLA ; G ; HCV ; Interferon ; α ; Ribavirin
• 刊名：Clinical and Experimental Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：17
• 期：1
• 页码：93-100
• 全文大小：
• 刊物主题：Internal Medicine; Hematology; Oncology;
• 出版者：Springer International Publishing
• ISSN：1591-9528
• 卷排序：17

文摘

The serum levels of soluble HLA class I antigens (sHLA-A, -B, -C and sHLA-G) were determined in 40 HCV genotype 1-infected patients before (Tb>0b>), after 3, 6, and 12 months (Tb>3b>, Tb>6b>, and Tb>12b>) of pegylated-IFN-α plus ribavirin therapy and 6 months (Tb>18b>) after the end of treatment. Twenty patients were sustained virological responders (SVR), and 20 were non-responders (NR). sHLA-A, -B, -C levels at Tb>0b> were significantly higher in both SVR (mean 10.48 μg/ml) and NR (mean 11.87 μg/ml) patients as compared to healthy controls (mean 0.34 μg/ml, p < 0.0001) and HIV-infected subjects (mean 1.22 μg/ml, p < 0.0001). sHLA-G levels at Tb>0b> were significantly higher in SVR (mean 24.78 ng/ml) and NR (mean 24.93 ng/ml) patients as compared to healthy controls (mean 10.34 ng/ml, p = 0.015 and p = 0.014, respectively) but were lower as compared to HIV-infected subjects (mean 48.00 ng/ml, p < 0.0001). The levels of sHLA-A, -B, -C and sHLA-G significantly decreased in SVR from Tb>0b> to Tb>18b> (mean 1.64 and 1.43 ng/ml, respectively, p < 0.0001) and correlated with HCV-RNA, AST, ALT, γGT, and ALP levels. The determination of soluble HLA class I levels could be proposed as a surrogate marker to discriminate SVR and NR HCV-infected patients during PEG-IFN-α plus ribavirin therapy.