Hepatitis E virus infection activates signal regulator protein α to down-regulate type I interferon

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• 作者：Fen Huang ; Chenchen Yang ; Wenhai Yu ; Yanhong Bi ; Feiyan Long…
• 关键词：Hepatitis E virus ; Signal regulator protein α ; IRF3 ; IFN ; β
• 刊名：Immunologic Research
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：64
• 期：1
• 页码：115-122
• 全文大小：1,629 KB
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• 作者单位：Fen Huang (1) (2)
  Chenchen Yang (1)
  Wenhai Yu (3)
  Yanhong Bi (1)
  Feiyan Long (1)
  Jue Wang (1)
  Yunlong Li (1)
  Shenrong Jing (1)
  
  1. Medical Faculty, Kunming University of Science and Technology, Kunming, People’s Republic of China
  2. Kunming General Hospital of Chengdu Military Region, Kunming, People’s Republic of China
  3. Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, 935 Jiaoling Road, Kunming, People’s Republic of China
  
• 刊物主题：Allergology; Immunology; Medicine/Public Health, general; Internal Medicine;
• 出版者：Springer US
• ISSN：1559-0755

文摘

Hepatitis E virus (HEV) is a major cause of enterically transmitted acute hepatitis worldwide. However, the mechanism of HEV replication is unclear. Type I interferon is the first defense line of host against viral infection. Signal regulator protein α (SIRP-α) plays an important role in negative regulation of innate immunity. In the present study, HEV infection significantly activated the expression of SIRP-α and down-regulated phosphorylation of IRF3, consequently resulted in suppression of type I interferon (IFN-β). In conclusion, HEV exploited SIRP-α to negative regulated IFN-β of the host innate immune system to promote viral infection. It suggested that interfering with the functions of SIRP-α should be considered as a potential therapeutic approach to the prevention and treatment of HEV infection. Keywords Hepatitis E virus Signal regulator protein α IRF3 IFN-β