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Changes in the serum level of hepatitis B virus (HBV) surface antigen over the natural course of HBV infection
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  • 作者:Akihiro Matsumoto (1) <br>Eiji Tanaka (1) etanaka@shinshu-u.ac.jp <br>Susumu Morita (1) <br>Kaname Yoshizawa (12) <br>Takeji Umemura (1) <br>Satoru Joshita (1)
  • 关键词:Hepatitis B virus &#8211 ; Hepatitis B surface antigen &#8211 ; Hepatitis B core ; related antigen &#8211 ; Serum level &#8211 ; Natural course
  • 刊名:Journal of Gastroenterology
  • 出版年:2012
  • 出版时间:September 2012
  • 年:2012
  • 卷:47
  • 期:9
  • 页码:1006-1013
  • 全文大小:350.4 KB
  • 参考文献:1. Lavanchy D. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat. 2004;11:97&#8211;107. <br>2. Hoofnagle JH, Doo E, Liang TJ, Fleischer R, Lok AS. Management of hepatitis B: summary of a clinical research workshop. Hepatology. 2007;45:1056&#8211;75. <br>3. Lok AS, McMahon BJ. Chronic hepatitis B. Hepatology. 2007;45:507&#8211;39. <br>4. Brunetto MR, Moriconi F, Bonino F, Lau GK, Farci P, Yurdaydin C, et al. Hepatitis B virus surface antigen levels: a guide to sustained response to peginterferon alfa-2a in HBeAg-negative chronic hepatitis B. Hepatology. 2009;49:1141&#8211;50. <br>5. Moucari R, Mackiewicz V, Lada O, Ripault MP, Castelnau C, Martinot-Peignoux M, et al. Early serum HBsAg drop: a strong predictor of sustained virological response to pegylated interferon alfa-2a in HBeAg-negative patients. Hepatology. 2009;49:1151&#8211;7. <br>6. Simonetti J, Bulkow L, McMahon BJ, Homan C, Snowball M, Negus S, et al. Clearance of hepatitis B surface antigen and risk of hepatocellular carcinoma in a cohort chronically infected with hepatitis B virus. Hepatology. 2010;51:1531&#8211;7. <br>7. Yuen MF, Wong DK, Fung J, Ip P, But D, Hung I, et al. HBsAg Seroclearance in chronic hepatitis B in Asian patients: replicative level and risk of hepatocellular carcinoma. Gastroenterology. 2008;135:1192&#8211;9. <br>8. Tseng TC, Kao JH. HBsAg seroclearance: the more and earlier, the better. Gastroenterology. 2009;136:1842&#8211;3. author reply 3&#8211;4. <br>9. Chu CM, Liaw YF. HBsAg seroclearance in asymptomatic carriers of high endemic areas: appreciably high rates during a long-term follow-up. Hepatology. 2007;45:1187&#8211;92. <br>10. Chan HL, Wong VW, Wong GL, Tse CH, Chan HY, Sung JJ. A longitudinal study on the natural history of serum hepatitis B surface antigen changes in chronic hepatitis B. Hepatology. 2010;52:1232&#8211;41. <br>11. Suzuki F, Miyakoshi H, Kobayashi M, Kumada H. Correlation between serum hepatitis B virus core-related antigen and intrahepatic covalently closed circular DNA in chronic hepatitis B patients. J Med Virol. 2009;81:27&#8211;33. <br>12. Kimura T, Ohno N, Terada N, Rokuhara A, Matsumoto A, Yagi S, et al. Hepatitis B virus DNA-negative dane particles lack core protein but contain a 22-kDa precore protein without C-terminal arginine-rich domain. J Biol Chem. 2005;280:21713&#8211;9. <br>13. Mizokami M, Nakano T, Orito E, Tanaka Y, Sakugawa H, Mukaide M, et al. Hepatitis B virus genotype assignment using restriction fragment length polymorphism patterns. FEBS Lett. 1999;450:66&#8211;71. <br>14. Tanaka E, Matsumoto A, Yoshizawa K, Maki N. Hepatitis B core-related antigen assay is useful for monitoring the antiviral effects of nucleoside analogue therapy. Intervirology. 2008;51(Suppl 1):3&#8211;6. <br>15. Lee WM. Hepatitis B virus infection. N Engl J Med. 1997;337:1733&#8211;45. <br>16. Chan HL, Wong VW, Tse AM, Tse CH, Chim AM, Chan HY, et al. Serum hepatitis B surface antigen quantitation can reflect hepatitis B virus in the liver and predict treatment response. Clin Gastroenterol Hepatol. 2007;5:1462&#8211;8. <br>17. Hosaka T, Suzuki F, Kobayashi M, Hirakawa M, Kawamura Y, Yatsuji H, et al. HBcrAg is a predictor of post-treatment recurrence of hepatocellular carcinoma during antiviral therapy. Liver Int. 2010;30:1461&#8211;70. <br>18. Wong DK, Tanaka Y, Lai CL, Mizokami M, Fung J, Yuen MF. Hepatitis B virus core-related antigens as markers for monitoring chronic hepatitis B infection. J Clin Microbiol. 2007;45:3942&#8211;7. <br>19. Matsumoto A, Tanaka E, Minami M, Okanoue T, Yatsuhashi H, Nagaoka S, et al. Low serum level of hepatitis B core-related antigen indicates unlikely reactivation of hepatitis after cessation of lamivudine therapy. Hepatol Res. 2007;37:661&#8211;6. <br>20. Shinkai N, Tanaka Y, Orito E, Ito K, Ohno T, Hirashima N, et al. Measurement of hepatitis B virus core-related antigen as predicting factor for relapse after cessation of lamivudine therapy for chronic hepatitis B virus infection. Hepatol Res. 2006;36:272&#8211;6. <br>21. Matsumoto A, Tanaka E, Suzuki Y, Kobayashi M, Tanaka Y, Shinkai N, et al. Combination of hepatitis B viral antigens and DNA for prediction of relapse after discontinuation of nucleos(t)ide analogues in patients with chronic hepatitis B. Hepatol Res. 2012;42:139&#8211;49.
  • 作者单位:1. Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan2. Department of Gastroenterology, National Hospital Organization Shinshu Ueda Medical Center, 1-27-21 Midorigaoka, Ueda, 386-8610 Japan
  • ISSN:1435-5922
文摘
Background Despite its status as a potential biomarker of hepatitis B virus (HBV) response to interferon treatment, the changes in hepatitis B surface antigen (HBsAg) levels over the natural course of HBV carriers have not been analyzed sufficiently.

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