Phytochemical characterization and effect of Calendula officinalis, Hypericum perforatum, and Salvia officinalis infusions on obesity-associated cardiovascular risk
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- 作者：Diego Hernández-Saavedra ; Iza F. Pérez-Ramírez…
- 关键词：Medicinal herbs ; Obesity ; Cardiovascular risk ; Oil tolerance test
- 刊名：Medicinal Chemistry Research
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：25
- 期：1
- 页码：163-172
- 全文大小：638 KB
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Iza F. Pérez-Ramírez (1)
Minerva Ramos-Gómez (1)
Sandra Mendoza-Díaz (1)
Guadalupe Loarca-Piña (1)
Rosalia Reynoso-Camacho (1)
1. Research and Graduate Studies in Food Science, School of Chemistry, Universidad Autonoma de Queretaro, Queretaro, 76010, Mexico - 刊物主题：Pharmacology/Toxicology; Biochemistry, general; Cell Biology;
- 出版者：Springer US
- ISSN：1554-8120
文摘
Medicinal herb infusions can be used for the treatment of obesity-related metabolic alterations. The aim of this study was to characterize the phytochemical profile and to evaluate the effect of Hypericum perforatum, Salvia officinalis, and Calendula officinalis on the cardiovascular risk developed in diet-induced obese rats. All infusions decreased body weight and abdominal fat mass and reduced serum triglycerides (TG), total cholesterol, low-density lipoproteins, and C-reactive protein levels. The anti-obesogenic and hypolipidemic effect of C. officinalis and H. perforatum were associated with the inhibition of triglycerides digestion and absorption. Conversely, the hypolipidemic effect of S. officinalis was not associated with this mechanism. Moreover, seven phenolic acids and nine flavonoids were quantified by HPLC–UV/VIS, hesperidin and epigallocatechin gallate were the majoritarian compounds of H. perforatum and C. officinalis, whereas rosmarinic and ellagic acids were the main compounds in S. officinalis. Additionally, we used HPLC–DAD–MSD to identify 45 phytochemicals, such as anthraquinone and phloroglucinol derivatives, phytosterols, saponins, and alkaloids. Total flavonoids, phytosterols, and alkaloids content were highly correlated with TG levels, AUC values from the oil tolerance test, and pancreatic lipase inhibition. These results suggest that these phytochemical-rich infusions may be used as an alternative for obesity-related cardiovascular risk treatment. Keywords Medicinal herbs Obesity Cardiovascular risk Oil tolerance test