Study of vortex-assisted MSPD and LC-MS/MS using alternative solid supports for pharmaceutical extraction from marketed fish

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• 作者：Gabriel I. Hertzog ; Karina L. Soares…
• 关键词：Pharmaceuticals ; Fish ; MSPD ; Alternative solid supports ; LC ; MS/MS
• 刊名：Analytical and Bioanalytical Chemistry
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：407
• 期：16
• 页码：4793-4803
• 全文大小：440 KB
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• 作者单位：Gabriel I. Hertzog (1)
  Karina L. Soares (1)
  Sergiane S. Caldas (1)
  Ednei G. Primel (1)
  
  1. Post-graduate Program in Technological and Environmental Chemistry, Escola de Química e Alimentos, Laboratório de Análise de Compostos Organicos e Metais (LACOM), Universidade Federal do Rio Grande, Av. Itália, km 8, Rio Grande, Rio Grande do Sul state, 96203-900, Brazil
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Analytical Chemistry
  Food Science
  Inorganic Chemistry
  Physical Chemistry
  Monitoring, Environmental Analysis and Environmental Ecotoxicology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1618-2650

文摘

A procedure based on vortex-assisted matrix solid-phase dispersion (MSPD) for the extraction of 15 pharmaceuticals from fish samples with determination by liquid chromatography-tandem mass spectrometry (LC-MS/MS) was validated. Florisil, C18, diatomaceous earth, chitin, and chitosan were evaluated as solid supports. Best results were obtained with 0.5?g of diatomaceous earth, 0.5?g of sodium sulfate, and 5?mL of methanol. Analytical recoveries ranged from 58 to 128?% with relative standard deviation (RSD) lower than 15?%. Limit of quantification (LOQ) values for the 15 compounds ranged from 5 to 1000?ng?g?. The method under investigation has shown to be a simple and fast extraction tool with minimum instrumentation and low amount of reagent, resulting in method low cost. Besides, alternative materials, such as chitin and chitosan, which were applied to the dispersion step for the first time, were found to be interesting alternatives.