Progression und Regression atherosklerotischer Plaques

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• 作者：Prof. Dr. med. Raimund Erbel FAHA ; FESC ; FASE ; FACC
• 关键词：Atherosklerose ; Koronare Herzerkrankung ; Progression ; Regression ; Statine ; Coronary atherosclerosis ; Coronary heart disease ; Progression ; Regression ; Statins
• 刊名：Herz
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：40
• 期：6
• 页码：855-862
• 全文大小：1,106 KB
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• 作者单位：Prof. Dr. med. Raimund Erbel FAHA, FESC, FASE, FACC (1)
  
  1. Institut für Medizinische Informatik, Biometrie und Epidemiologie, Universit?tsklinikum Essen, Universit?t Duisburg-Essen, Hufelandstr 55, 45147, Essen, Deutschland
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Cardiology
  
• 出版者：Urban & Vogel
• ISSN：1615-6692

文摘

Intravascular ultrasound has been established as the gold standard for analyzing alterations in coronary artery atherosclerosis during monitoring investigations. Cross-sectional imaging can be used to visualize the area of the lumen and the vessel size and the plaque size as the difference between them. New technology allows the 3-D reconstruction of the volume for prespecified vessel segments using specific algorithms. Investigations on the natural course demonstrated predominantly progression. Even regression of coronary atherosclerosis can be visualized and quantified. Regression can only be expected when the level of low-density lipoprotein (LDL) cholesterol is below the critical level of 75 mg/dl. Prospective randomized studies with highly effective statins showed that regression occurred in up to two thirds of patients when LDL cholesterol was below a cut-off of 78 mg/dl and was, therefore, very close to the threshold, which was calculated based on investigations of the natural course. Although the absolute values for plaque volume are in the range of 1- over 1- years, it must be taken into consideration that coronary artery diseases are chronic diseases and a 1- change per year will correspond to an enormous effect on plaque growth of coronary vessels. The great success of statins in reducing cardiovascular events is due to the possibility for reduction of progression and induction of regression. New developments in medication will be measured against the effectiveness of statins. Keywords Coronary atherosclerosis Coronary heart disease Progression Regression Statins