Correlation between Gd-EOB-DTPA-enhanced MR imaging findings and OATP1B3 expression in chemotherapy-associated sinusoidal obstruction syndrome

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• 作者：Norihide Yoneda ; Osamu Matsui ; Hiroshi Ikeno ; Dai Inoue…
• 关键词：Sinusoidal obstruction syndrome ; Oxaliplatin ; OATP1B3 ; Gd ; EOB ; DTPA
• 刊名：Abdominal Imaging
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：40
• 期：8
• 页码：3099-3103
• 全文大小：1,102 KB
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• 作者单位：Norihide Yoneda (1)
  Osamu Matsui (1)
  Hiroshi Ikeno (1)
  Dai Inoue (1)
  Kotaro Yoshida (1)
  Azusa Kitao (1)
  Kazuto Kozaka (1)
  Satoshi Kobayashi (1)
  Toshifumi Gabata (1)
  Hiroko Ikeda (2)
  Keishi Nakamura (3)
  Tetsuo Ohta (3)
  
  1. Department of Radiology, Kanazawa University Hospital, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan
  2. Division of Pathology, Kanazawa University Hospital, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan
  3. Department of Gastroenterologic Surgery, Kanazawa University Hospital, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Imaging and Radiology
  Gastroenterology
  Hepatology
  
• 出版者：Springer New York
• ISSN：1432-0509

文摘

We report a female case of sinusoidal obstruction syndrome (SOS) diagnosed pathologically after chemotherapy (Pmab+m-FOLFOX6) for ascending colon cancer with multiple liver metastases, focusing on the findings of gadoxetic acid-enhanced MRI (EOB-MRI) and the organic anion transporting polypeptide 1B3 (OATP1B3) expression of in the liver. The patient was a 75-year-old female. She had received chemotherapy (Pmab+m-FOLFOX6) as six cycles for preoperative chemotherapy. After the preoperative chemotherapy, tumor sizes of hepatic metastases were reduced and hepatobiliary phase of EOB-MRI clearly depicted diffuse reticular hypointensity in the background liver. On the other hand, dynamic CT and/or other sequences of EOB-MRI did not show definite abnormality in the background liver. After the operation, this patient was pathologically confirmed as SOS demonstrating centrilobular congestion, sinusoidal dilatation, and perisinusoidal fibrosis. In normal liver parenchyma, OATP1B3 (uptake transporter of the EOB-MRI) expression is observed predominantly in centrilobular hepatocytes (zone 3). On the other hand, OATP1B3 expression was remarkably reduced because of the damages in the centrilobular (zone 3) hepatocytes in this SOS case. This indicated that EOB-MRI might be extremely sensitive in diagnosing SOS in its early stage. Keywords Sinusoidal obstruction syndrome Oxaliplatin OATP1B3 Gd-EOB-DTPA