MS_HistoneDB, a manually curated resource for proteomic analysis of human and mouse histones

详细信息    查看全文

• 作者：Sara El Kennani ; Annie Adrait ; Alexey K. Shaytan ; Saadi Khochbin…
• 关键词：Histone ; Histone variants ; Chromatin ; Mass spectrometry ; Proteomics
• 刊名：Epigenetics & Chromatin
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：10
• 期：1
• 全文大小：1458KB
• 刊物主题：Animal Genetics and Genomics; Human Genetics; Plant Genetics & Genomics; Cell Biology; Gene Expression; Gene Function;
• 出版者：BioMed Central
• ISSN：1756-8935
• 卷排序：10

文摘

BackgroundHistones and histone variants are essential components of the nuclear chromatin. While mass spectrometry has opened a large window to their characterization and functional studies, their identification from proteomic data remains challenging. Indeed, the current interpretation of mass spectrometry data relies on public databases which are either not exhaustive (Swiss-Prot) or contain many redundant entries (UniProtKB or NCBI). Currently, no protein database is ideally suited for the analysis of histones and the complex array of mammalian histone variants.