The association between the poly(A) polymorphism in the VDR gene and cancer risk: a meta-analysis

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• 作者：Jin Huang (1)
  Jiqiao Yang (1)
  Haichuan Wang (1)
  Tianyuan Xiong (1)
  Hongbo Zhang (2)
  Yaxian Ma (1)
  Xiaoze Wang (1)
  Jichong Huang (1)
  Liang Du (3)
  
• 关键词：Vitamin D receptor ; Poly(A) ; Polymorphism ; Cancer ; Meta ; analysis
• 刊名：Tumor Biology
• 出版年：2013
• 出版时间：June 2013
• 年：2013
• 卷：34
• 期：3
• 页码：1833-1838
• 全文大小：330KB
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• 作者单位：Jin Huang (1)
  Jiqiao Yang (1)
  Haichuan Wang (1)
  Tianyuan Xiong (1)
  Hongbo Zhang (2)
  Yaxian Ma (1)
  Xiaoze Wang (1)
  Jichong Huang (1)
  Liang Du (3)
  
  1. West China Medical School/West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China
  2. The Second Medical School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 610000, China
  3. The Periodical Press of West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China
  
• ISSN：1423-0380

文摘

The poly(A) polymorphism (L/S) in the VDR gene has been implicated in susceptibility of cancer, but a number of studies have reported inconclusive results. The aim of this study is to investigate the relationship between the poly(A) polymorphism in the VDR gene and cancer risk by meta-analysis. We searched PubMed database, EMBASE database, CNKI database, and Wanfang database, covering all studies until January 22, 2013. Statistical analysis was performed by using the software Revman4.2 and STATA 10.0. A total 8,186 cancer cases and 8,685 controls in 19 case–control studies from 15 studies were identified for data analysis. The results suggested that the S allele carriers (SS-?SL) did not have an increased or decreased risk of cancer when compared with the homozygote LL carriers (odds ratio (OR)--.96, 95?% CI--.87-.06, P--.43 for SS-?SL vs. LL). In addition, in the subgroup analysis by ethnicity and cancer type, no significant association was found among Caucasians, African-Americans, prostate cancer, or breast cancer. This current meta-analysis suggested that the poly(A) polymorphism in the VDR gene may not contribute to the risk of cancer. Future studies are needed to validate our findings.