Intermolecular dearomative oxidative coupling of indoles with ketones and sulfonylhydrazines catalyzed by I₂: synthesis of [2,3]-fused indoline tetrahydropyridazines

详细信息    查看全文

• 作者：Feng Wei ; Liang Cheng ; Hongyan Huang ; Jiejie Liu ; Dong Wang…
• 关键词：iodine ; indoline ; oxidative coupling ; hydrazones ; three ; component ; tetrahydropyridazines
• 刊名：SCIENCE CHINA Chemistry
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：59
• 期：10
• 页码：1311-1316
• 全文大小：1,806 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Chinese Library of Science
  Chemistry
  
• 出版者：Science China Press, co-published with Springer
• ISSN：1869-1870
• 卷排序：59

文摘

A convergent construction of [2,3]-fused indoline tetrahydropyridazines via an I₂/tert-butyl hydroperoxide (TBHP) catalyzed three-component dearomative oxidative coupling of indoles, hydrazines and acetophenone was established in moderate to good yields. This protocol provides a new approach for the synthesis of these biologically interesting fused indolines.