Effects of High-Fat Diet on Neuronal Damage, Gliosis, Inflammatory Process and Oxidative Stress in the Hippocampus Induced by Transient Cerebral Ischemia
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- 作者：Bing Chun Yan (1) (2)
Joon Ha Park (3)
Ji Hyeon Ahn (3)
In Hye Kim (3)
Jae-Chul Lee (3)
Ki-Yeon Yoo (4)
Jung Hoon Choi (5)
In Koo Hwang (6)
Jun Hwi Cho (7)
Young-Guen Kwon (8)
Young-Myeong Kim (9)
Choong Hyun Lee (10)
Moo-Ho Won (3) - 关键词：High ; fat diet ; Transient cerebral ischemia ; Glial activation ; Inflammatory cytokines ; Oxidative stress
- 刊名：Neurochemical Research
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：39
- 期：12
- 页码：2465-2478
- 全文大小：11,200 KB
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Joon Ha Park (3)
Ji Hyeon Ahn (3)
In Hye Kim (3)
Jae-Chul Lee (3)
Ki-Yeon Yoo (4)
Jung Hoon Choi (5)
In Koo Hwang (6)
Jun Hwi Cho (7)
Young-Guen Kwon (8)
Young-Myeong Kim (9)
Choong Hyun Lee (10)
Moo-Ho Won (3)
1. Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou, 225001, China
2. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, China
3. Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, 200-701, South Korea
4. Department of Oral Anatomy, College of Dentistry, Research Institute of Oral Sciences, Gangneung-Wonju National University, Gangneung, 210-702, South Korea
5. Department of Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon, 200-701, South Korea
6. Department of Anatomy and Cell Biology, College of Veterinary Medicine, Research Institute for Veterinary Science, Seoul National University, Seoul, 151-742, South Korea
7. Department of Emergency Medicine, Institute of Medical Sciences, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, 200-701, South Korea
8. Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, 120-749, South Korea
9. Department of Molecular and Cellular Biochemistry, Vascular System Research Center, School of Medicine, Kangwon National University, Chuncheon, 200-701, South Korea
10. Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan, 330-714, South Korea - ISSN：1573-6903
文摘
In this study, we investigated the effects of a normal diet (ND) and high-fat diet (HFD) on delayed neuronal death in the gerbil hippocampal CA1 region after transient cerebral ischemia. In the HFD-fed gerbils, ischemia-induced hyperactivity was significantly increased and neuronal damage was represented more severely compared to the ND-fed gerbils. Ischemia-induced glial activation was accelerated in the HFD-fed gerbils. Cytokines including interleukin-2 and -4 were more sensitive in the hippocampal CA1 region of the HFD-fed gerbils after ischemia-reperfusion. Additionally, we found that decreased 4-HNE and SODs immunoreactivity and protein levels in the hippocampal CA1 region of the HFD-fed gerbils after ischemia-reperfusion. These results indicate that HFD may lead to the exacerbated effects on ischemia-induced neuronal death in the hippocampal CA1 region after ischemia-reperfusion. These effects of HFD may be associated with more accelerated activations of glial cells and imbalance of pro- and anti-inflammatory cytokines and/or antioxidants after transient cerebral ischemia.