CYP4F2 genetic polymorphisms are associated with coronary heart disease in a Chinese population

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• 作者：Changqing Yu (1) (2)
  Qingkai Yan (1) (2)
  Chunjiang Fu (1) (2)
  Weibin Shi (1) (2)
  Hongyong Wang (1) (2)
  Chunyu Zeng (1) (2)
  Xukai Wang (1) (2)
  
  1. Department of Cardiology ; Daping Hospital ; The Third Military Medical University ; 10#Changjiangzhilu ; Yuzhong District ; Chongqing ; 400042 ; People鈥檚 Republic of China
  2. Chongqing Institute of Cardiology ; 10#Changjiangzhilu ; Yuzhong District ; Chongqing ; 400042 ; People鈥檚 Republic of China
  
• 关键词：Coronary heart disease ; CYP4F2 gene ; Single nucleotide polymorphism
• 刊名：Lipids in Health and Disease
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：13
• 期：1
• 全文大小：204 KB
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• 刊物主题：Lipidology; Medical Biochemistry;
• 出版者：BioMed Central
• ISSN：1476-511X

文摘

Background To explore the relationship between CYP4F2 gene polymorphism and coronary heart disease (CHD) in a Chinese Han population. Methods We selected 440 CHD patients and 440 control subjects to perform a case - control study. Four SNPs (rs2108622, rs3093100, rs3093105 and rs3093135) in CYP4F2 gene were genotyped using polymerase chain reaction - restriction fragment length polymorphism (PCR - RFLP) methods. The genotype and haplotype distributions were compared between the case and the control group. Results We found both rs2108622 and rs3093105 in CYP4F2 gene were associated with the risk for CHD (P P Conclusion CYP4F2 gene polymorphisms were associated with the risk of CHD in Chinese population.