Correlation of In Vitro
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- 作者：Milce Costa ; XistoSena Passos ; AndréThiagoBorges Miranda ; RosaneSilvaCarneiro de Araújo ; Claudete Rodrigues Paula and MariadoRosário Rodrigues Silva
- 关键词：Fluconazole ; in vitro susceptibility ; itraconazole ; vaginal candidiasis
- 刊名：Mycopathologia
- 出版年：2004
- 出版时间：2004
- 年：2004
- 卷：157
- 期：1
- 页码：43-47
- 全文大小：68 KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Life Sciences
Microbiology
Medical Microbiology
Plant Sciences
Microbial Ecology - 出版者：Springer Netherlands
- ISSN：1573-0832
文摘
Between April 2001 and April 2002 were studied 106 women with a clinical diagnosis of vaginal candidiasis seen at the Gynecology and Obstetrics Ambulatory of the Hospital das Clínicas da Universidade Federal de Goiás. The patients were assessed on two occasions, before starting treatment with itraconazole or fluconazole (initial visit) and 14 days after treatment (return). At two visits the signs and symptoms were recorded and vaginal secretion was collected. According to the clinical evaluation, itraconazole was effective in 64.3%, while fluconazole was effective in 71.0% of the patients. The mycological cure rates (negative culture) in the return were 64.3% for the patients treated with itraconazole and 78.9% for the patients treated with fluconazole. The MICs of itraconazole and fluconazole for 80 Candida isolates were determined by Etest method. We investigated the correlation between in vitro susceptibility (Susceptible, Susceptibility Depending Dose and Resistant) to itraconazole and fluconazole with clinical outcome of the patients.The success rates were 63.9% for itraconazole and 90.6% for fluconazole in the susceptible category, 100.0% for both drugs in the susceptible dose dependent category, and 0.0% for both drugs in the resistant category. Our results showed there were a positive correlation between in vitro susceptibility test results with clinical outcome in vaginal Candida infections and that both drugs might be one choice in the treatment of vaginal candidiasis.