Mercury and psychosocial stress exposure interact to predict maternal diurnal cortisol during pregnancy

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• 作者：Hannah MC Schreier ; Hsiao-Hsien Hsu ; Chitra Amarasiriwardena…
• 关键词：Mercury ; Psychosocial ; Stress ; Pregnancy ; Cortisol ; HPA axis
• 刊名：Environmental Health
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：14
• 期：1
• 全文大小：556 KB
• 参考文献：1. Van Cauter, E Endocrine rhythms. In: Becker, KL eds. (1995) Principles and Practice of Endocrinology and Metabolism. J. B. Lippincott Company, Philadelphia, pp. 41-50
  2. Wadhwa, PD (2005) Psychoneuroendocrine processes in human pregnancy influence fetal development and health. Psychoneuroendocrinology 30: pp. 724-743 CrossRef
  3. Weinstock, M (2005) The potential influence of maternal stress hormones on development and mental health of the offspring. Brain Behav Immun 19: pp. 296-308 CrossRef
  4. O'Donnell, K, O'Connor, TG, Glover, V (2009) Prenatal stress and neurodevelopment of the child: focus on the HPA axis and role of the placenta. Dev Neurosci 31: pp. 285-292 CrossRef
  5. Cory-Slechta, DA, Virgolini, MB, Rossi-George, A, Thiruchelvam, M, Lisek, R, Weston, D (2008) Lifetime consequences of combined maternal lead and stress. Basic Clin Pharmacol Toxicol 102: pp. 218-227 CrossRef
  6. Gump, BB, Stewart, P, Reihman, J (2008) Low-level prenatal and postnatal blood lead exposure and adrenocortical responses to acute stress in children. Environ Health Perspect 116: pp. 249 CrossRef
  7. Levine, S (2000) Influence of psychological variables on the activity of the hypothalamic–pituitary–adrenal axis. Eur J Pharmacol 405: pp. 149-160 CrossRef
  8. Miller, GE, Chen, E, Zhou, ES (2007) If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans. Psychol Bull 133: pp. 25 CrossRef
  9. Dickerson, SS, Kemeny, ME (2004) Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Psychol Bull 130: pp. 355 CrossRef
  10. Diego, MA, Jones, NA, Field, T, Hernandez-Reif, M, Schanberg, S, Kuhn, C (2006) Maternal psychological distress, prenatal cortisol, and fetal weight. Psychosom Med 68: pp. 747-753 CrossRef
  11. Obel, C, Hedegaard, M, Henriksen, TB, Secher, NJ, Olsen, J, Levine, S (2005) Stress and salivary cortisol during pregnancy. Psychoneuroendocrinology 30: pp. 647-656 CrossRef
  12. Pluess, M, Bolten, M, Pirke, K-M (2010) Maternal trait anxiety, emotional distress, and salivary cortisol in pregnancy. Biol Psychol 83: pp. 169-175 CrossRef
  13. Bolten, MI, Wurmser, H, Buske-Kirschbaum, A, Papusek, M, Pirke, KM, Hellhammer, D (2011) Cortisol levels in pregnancy as a psychobiological predictor for birth weight. Arch Womens Ment Health 14: pp. 33-41 CrossRef
  14. LeWinn, KZ, Stroud, LR, Molnar, BE, Ware, JH, Koenen, KC, Bulka, SL (2009) Elevated maternal cortisol levels during pregnancy are associated with reduced childhood IQ. Int J Epidemiol 38: pp. 1700-1710 CrossRef
  15. Wright, RJ, Fisher, K, Chiu, YH, Wright, RO, Fein, R, Cohen, S (2013) Disrupted prenatal maternal cortisol, maternal obesity, and childhood wheeze. Insights into prenatal programming. Am J Respir Crit Care Med 187: pp. 1186-1193 CrossRef
  16. Tan, SW, Meiller, JC, Mahaffey, KR (2009) The endocrine effects of mercury in humans and wildlife. Crit Rev Toxicol 39: pp. 228-269 CrossRef
  17. Brkljacic, J, Milutinovic, DV, Dundjerski, J, Matic, G (2004) Mercury stimula
• 刊物主题：Environmental Health; Occupational Medicine/Industrial Medicine; Public Health;
• 出版者：BioMed Central
• ISSN：1476-069X

文摘

Background Disrupted maternal prenatal cortisol production influences offspring development. Factors influencing the hypothalamic-pituitary-adrenal axis include social (e.g., stressful life events) and physical/chemical (e.g., toxic metals) pollutants. Mercury (Hg) is a common contaminant of fish and exposure is widespread in the US. No prior study has examined the joint associations of stress and mercury with maternal cortisol profiles in pregnancy. Objectives To investigate potential synergistic influences of prenatal stress and Hg exposures on diurnal cortisol in pregnant women. Methods Analyses included 732 women (aged 27.4?±-.6?years) from a Mexico City pregnancy cohort. Participants collected saliva samples on two consecutive days (mean 19.52?±-.00?weeks gestation) and reported life stressors over the past 6?months. Hg was assessed in toe nail clippings collected during pregnancy. Results There were no main effects of Hg or psychosocial stress exposure on diurnal cortisol (ps--20) but strong evidence of interaction effects on cortisol slope (interaction B--006, SE--003, p--034) and cortisol at times 1 and 2 (interaction B--.071, SE--028, p--013; B--.078, SE--032, p--014). Women above the median for Hg and psychosocial stress exposure experienced a blunted morning cortisol response compared to women exposed to higher stress but lower Hg levels. Conclusions Social and physical environmental factors interact to alter aspects of maternal diurnal cortisol during pregnancy. Research focusing solely on either domain may miss synergistic influences with potentially important consequences to the offspring.