Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia

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• 作者：H. Dean Hosgood III (1) hosgoodd@mail.nih.gov
  Wen-Chang Wang (2)
  Yun-Chul Hong (34)
  Jiu-Cun Wang (5)
  Kexin Chen (6)
  I-Shou Chang (7)
  Chien-Jen Chen (89)
  Daru Lu (5)
  Zhihua Yin (10)
  Chen Wu (11)
  Wei Zheng (12)
  Biyun Qian (6)
  Jae Yong Park (131415)
  Yeul Hong Kim (161718)
  Nilanjan Chatterjee (1)
  Ying Chen (19)
  Gee-Chen Chang (20212236)
  Chin-Fu Hsiao (2)
  Meredith Yeager (123)
  Ying-Huang Tsai (2425)
  Hu Wei (1)
  Young Tae Kim (2627)
  Wei Wu (10)
  Zhenhong Zhao (5)
  Wong-Ho Chow (1)
  Xiaoling Zhu (6)
  Yen-Li Lo (2)
  Sook Whan Sung (2829)
  Kuan-Yu Chen (30)
  Jeff Yuenger (123)
  Joo Hyun Kim (27)
  Liming Huang (11)
  Ying-Hsiang Chen (2)
  Yu-Tang Gao (31)
  Jin Hee Kim (34)
  Ming-Shyan Huang (3233)
  Tae Hoon Jung (13)
  Neil Caporaso (1)
  Xueying Zhao (5)
  Zhang Huan (6)
  Dianke Yu (11)
  Chang Ho Kim (13)
  Wu-Chou Su (34)
  Xiao-Ou Shu (12)
  In-San Kim (14)
  Bryan Bassig (1)
  Yuh-Min Chen (3536)
  Sung Ick Cha (13)
  Wen Tan (11)
  Hongyan Chen (5)
  Tsung-Ying Yang (20)
  Jae Sook Sung (1617)
  Chih-Liang Wang (24)
  Xuelian Li (10)
  Kyong Hwa Park (1618)
  Chong-Jen Yu (30)
  Jeong-Seon Ryu (37)
  Yongbing Xiang (31)
  Amy Hutchinson (123)
  Jun Suk Kim (161718)
  Qiuyin Cai (12)
  Maria Teresa Landi (1)
  Kyoung-Mu Lee (3)
  Jen-Yu Hung (3233)
  Ju-Yeon Park (26)
  Margaret Tucker (1)
  Chien-Chung Lin (34)
  Yangwu Ren (10)
  Reury-Perng Perng (35)
  Chih-Yi Chen (38)
  Li Jin (5)
  Kun-Chieh Chen (20)
  Yao-Jen Li (9)
  Yu-Fang Chiu (2)
  Fang-Yu Tsai (7)
  Pan-Chyr Yang (30)
  Joseph F. Fraumeni Jr. (1)
  Adeline Seow (19)
  Dongxin Lin (11)
  Baosen Zhou (10)
  Stephen Chanock (123)
  Chao Agnes Hsiung (2)
  Nathaniel Rothman (1)
  Qing Lan (1)
• 刊名：Human Genetics
• 出版年：2012
• 出版时间：July 2012
• 年：2012
• 卷：131
• 期：7
• 页码：1197-1203
• 全文大小：227.5 KB
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• 作者单位：1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., EPS 8118, MCS 7240, Bethesda, MD 20892-7240, USA2. Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan3. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea4. Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea5. Ministry of Education Key Laboratory of Contemporary Anthropology, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, 200433 China6. Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Hospital and Institute, Tianjin, 300060 People’s Republic of China7. National Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan8. Genomics Research Center, Academia Sinica, Taipei, Taiwan9. Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan10. Department of Epidemiology, School of Public Health, China Medical University, No 92 North Second Road, Heping District, Shenyang, 110001 People’s Republic of China11. Departments of Etiology and Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China12. Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Institute for Medicine and Public Health, Vanderbilt University School of Medicine, Nashville, TN, USA13. Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea14. Department of Biochemistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea15. Cancer Research Center, Kyungpook National University Hospital, Daegu, Republic of Korea16. Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Anam Hospital, Seoul, Republic of Korea17. Division of Brain, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea18. Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea19. Department of Epidemiology and Public Health, National University of Singapore, Singapore, Singapore20. Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan21. Institute of Biomedical Sciences, National Chung-Hsing University, Taichung, Taiwan22. School of Medicine, China Medical University, Taichung, Taiwan23. Department of Health and Human Services, Core Genotyping Facility, Advanced Technology Program, Science Applications International Corporation-Frederick, National Cancer Institute, National Institutes of Health, Frederick, MD, USA24. Department of Pulmonary and Critical Care, Chang Gung Memorial Hospital, Chia Yi, Taiwan25. Department of Respiratory Care, Chang Gung University, Taoyuan, Taiwan26. Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea27. Department of Thoracic and Cardiovascular Surgery, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea28. Department of Thoracic and Cardiovascular Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea29. Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Geongi-do, Republic of Korea30. Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan31. Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China32. School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan33. Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan34. Department of Internal Medicine, National Cheng Kung University Hospital and College of Medicine, Tainan, Taiwan35. Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan36. School of Medicine, National Yang-Ming University, Taipei, Taiwan37. Department of Internal Medicine, Inha University College of Medicine, Incheon, Republic of Korea38. Cancer Center, China Medical University Hospital, Taipei, Taiwan
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Human Genetics
  Molecular Medicine
  Internal Medicine
  Metabolic Diseases
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1203

文摘

A recent genome-wide association study (GWAS) of subjects from Japan and South Korea reported a novel association between the TP63 locus on chromosome 3q28 and risk of lung adenocarcinoma (p = 7.3 × 10?12); however, this association did not achieve genome-wide significance (p ≤ 10?7) among never-smoking males or females. To determine if this association with lung cancer risk is independent of tobacco use, we genotyped the TP63 SNPs reported by the previous GWAS (rs10937405 and rs4488809) in 3,467 never-smoking female lung cancer cases and 3,787 never-smoking female controls from 10 studies conducted in Taiwan, Mainland China, South Korea, and Singapore. Genetic variation in rs10937405 was associated with risk of lung adenocarcinoma [n = 2,529 cases; p = 7.1 × 10?8; allelic risk = 0.80, 95% confidence interval (CI) = 0.74–0.87]. There was also evidence of association with squamous cell carcinoma of the lung (n = 302 cases; p = 0.037; allelic risk = 0.82, 95% CI = 0.67–0.99). Our findings provide strong evidence that genetic variation in TP63 is associated with the risk of lung adenocarcinoma among Asian females in the absence of tobacco smoking.