The Anti-Inflammatory Effect and Intestinal Barrier Protection of HU210 Differentially Depend on TLR4 Signaling in Dextran Sulfate Sodium-Induced Murine Colitis
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- 作者：Sisi Lin ; Yongyu Li ; Li Shen ; Ruiqin Zhang ; Lizhi Yang…
- 关键词：Ulcerative colitis ; HU210 ; Intestinal barrier function ; Toll ; like receptor 4 ; p38 mitogen ; activated protein kinase
- 刊名：Digestive Diseases and Sciences
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：62
- 期：2
- 页码：372-386
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Gastroenterology; Hepatology; Oncology; Transplant Surgery; Biochemistry, general;
- 出版者：Springer US
- ISSN：1573-2568
- 卷排序：62
文摘
BackgroundUlcerative colitis (UC) is strongly associated with inflammation and intestinal barrier disorder. The nonselective cannabinoid receptor agonist HU210 has been shown to ameliorate inflamed colon in colitis, but its effects on intestinal barrier function and extraintestinal inflammation are unclear.