Genetic effect of interleukin-1 beta (C-511T) polymorphism on the structural covariance network and white matter integrity in Alzheimer’s disease

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• 作者：Chi-Wei Huang ; Shih-Wei Hsu ; Shih-Jen Tsai ; Nai-Ching Chen…
• 关键词：Alzheimer’s disease ; Anatomical structural covariance ; Interleukin ; 1 beta polymorphism ; Salience network ; Executive control network
• 刊名：Journal of Neuroinflammation
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：14
• 期：1
• 全文大小：2357KB
• 刊物主题：Neurosciences; Neurology; Neurobiology; Immunology;
• 出版者：BioMed Central
• ISSN：1742-2094
• 卷排序：14

文摘

BackgroundInflammatory processes play a pivotal role in the degenerative process of Alzheimer’s disease. In humans, a biallelic (C/T) polymorphism in the promoter region (position-511) (rs16944) of the interleukin-1 beta gene has been significantly associated with differences in the secretory capacity of interleukin-1 beta. In this study, we investigated whether this functional polymorphism mediates the brain networks in patients with Alzheimer’s disease.